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Characterization of redox environment and tryptophan catabolism through kynurenine pathway in military divers’ and swimmers’ serum samples

dc.creatorSánchez Chapul, Lauraes_ES
dc.creatorPérez de la Cruz, Gonzaloes_ES
dc.creatorRamos Chávez, Lucio Antonioes_ES
dc.creatorValencia León, Jesús F.es_ES
dc.creatorTorres Beltrán, Joeles_ES
dc.creatorEstrada Camarena, Erikaes_ES
dc.creatorCarillo Mora, Paules_ES
dc.creatorRamírez Ortega, Danielaes_ES
dc.creatorBaños Vázquez, José U.es_ES
dc.creatorMartínez Nava, Gabrielaes_ES
dc.creatorLuna Angulo, Alexandraes_ES
dc.creatorMartínez Canseco, Carloses_ES
dc.creatorWences Chirino, Tiffany Y.es_ES
dc.creatorRíos Martínez, Juanes_ES
dc.creatorPérez de la Cruz, Verónicaes_ES
dc.date2022
dc.date.accessioned2024-12-06T18:02:33Z
dc.date.available2024-12-06T18:02:33Z
dc.date.issued2022
dc.identifierJC02NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8138
dc.identifier.urihttps://doi.org/10.3390/antiox11071223
dc.descriptionEndurance and resistance exercises, alone or in combination, induce metabolic changes that affect tryptophan (Trp) catabolism. The kynurenine pathway (KP) is the main route of Trp degradation, and it is modulated by the inflammatory and redox environments. Previous studies have shown that KP metabolites work as myokines that mediate the positive systemic effects related to exercise. However, it is poorly understood how different exercise modalities and intensities impact the KP. The aim of this study was to characterize the effect of two different exercise modalities, military diving and swimming, on the KP and the redox environment. A total of 34 healthy men from the Mexican Navy were included in the study, 20 divers and 14 swimmers, who started and stayed in military training consistently during the six months of the study; 12 Mexican men without fitness training were used as the control group. Physical fitness was determined at the beginning and after 6 months of training; criteria included body composition; serum levels of Trp, kynurenine (KYN), kynurenic acid (KYNA) and 3-hydroxykynurenine (3-HK); the glutathione ratio (GSH/GSSG); and malondialdehyde (MDA).. Results showed a significant loss of body fat in both the diver and swimmer groups. Compared with the control group, divers showed a decrease in Trp and 3-HK levels, but no changes were observed in the KYN/Trp, KYNA/Trp or 3-HK/Trp ratios, while swimmers showed a decrease in KYN levels and an increase in the KYNA and 3-HK levels. Additionally, divers showed a decrease in the GSH/GSSG ratio and an increase in MDA levels, in contrast to the swimmers, who showed a decrease in MDA levels and an increase in GSH/GSSG levels. Our findings suggest a differential shift in the KP and redox environment induced by diving and swimming. Swimming promotes an antioxidant environment and a peripheral overactivation of the KP.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.relation11(7):1223
dc.rightsAcceso Cerradoes_ES
dc.titleCharacterization of redox environment and tryptophan catabolism through kynurenine pathway in military divers’ and swimmers’ serum sampleses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Enfermedades Neuromusculares, División de Neurociencias Clínicas, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Mexico City 14389, Mexico
dc.contributor.emailabluna@inr.gob.mx (A.L.A.) ; tiff.wen@ciencias.unam.mx (T.Y.W.C.)
dc.relation.jnabreviadoANTIOXIDANTS (BASEL)
dc.relation.journalAntioxidants
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2076-3921
dc.identifier.doi10.3390/antiox11071223
dc.subject.kwTryptophan catabolism
dc.subject.kwKynurenic acid
dc.subject.kwEndurance exercise
dc.subject.kwRedox environment


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