Mostrar el registro sencillo del ítem

Exploring candidate gene studies and alexithymia: a systematic review

dc.creatorHernández-Díaz, Yasmínes_ES
dc.creatorGenis-Mendoza, Alma Deliaes_ES
dc.creatorGonzález-Castro, Thelma Beatrizes_ES
dc.creatorFresán, Anaes_ES
dc.creatorTovilla-Zárate, Carlos Alfonsoes_ES
dc.creatorLópez-Narváez, María Liliaes_ES
dc.creatorJuárez-Rojop, Isela Estheres_ES
dc.creatorNicolini, Humbertoes_ES
dc.date2024
dc.date.accessioned2024-10-04T17:20:02Z
dc.date.available2024-10-04T17:20:02Z
dc.date.issued2024
dc.identifier2024es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8067
dc.identifier.urihttps://doi.org/10.3390/genes15081025
dc.descriptionBackground: Alexithymia is a trait involving difficulties in processing emotions. Genetic association studies have investigated candidate genes involved in alexithymia's pathogenesis. Therefore, the aim of the present study was to perform a systematic review of the genetic background associated with alexithymia. Methods: A systematic review of genetic studies of people with alexithymia was conducted. Electronic databases including PubMed, Scopus, and Web of Science were searched for the study purpose. We used the words "Alexithymia", "gene", "genetics", "variants", and "biomarkers". The present systematic review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement. We found only candidate gene studies. A total of seventeen studies met the eligibility criteria, which comprised 22,361 individuals. The candidate genes associated with alexithymia were the serotoninergic pathway genes solute carrier family 6 member 4 (SLC6A4), serotonin 1A receptor (HTR1A), and serotonin 1A receptor (HTR2A); the neurotransmitter metabolism genes dopamine receptor D2 (DRD2), ankyrin repeat and kinase domain containing 1 (ANKK1), catechol-o-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF), and oxytocin receptor (OXTR); and other pathway genes, vitamin D-binding protein (VDBP), tumor protein P53 regulated apoptosis inducing protein 1 (TP53AIP1), Rho GTPase Activating Protein 32 (ARHGAP32), and transmembrane protein 88B (TMEM88B). Conclusion: The results of this study showed that only case-control gene studies have been performed in alexithymia. On the basis of our findings, the majority of alexithymia genes and polymorphisms in this study belong to the serotoninergic pathway and neurotransmitter metabolism genes. These data suggest a role of serotoninergic neurotransmission in alexithymia. Nevertheless, more and future research is required to learn about the role of these genes in alexithymia.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation15(8):1025
dc.rightsAcceso Cerradoes_ES
dc.titleExploring candidate gene studies and alexithymia: a systematic reviewes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDivisión Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez 86205, Mexico
dc.contributor.emailthebeagoncas@gmail.com (T.B.G.-C.), hnicolini@inmegen.gob.mx (H.N.)
dc.relation.jnabreviadoGENES
dc.relation.journalGenes
dc.identifier.placeSuiza
dc.date.published2024
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2073-4425
dc.identifier.doi10.3390/genes15081025
dc.subject.kwAlexithymia
dc.subject.kwGenes
dc.subject.kwBiomarkers


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem