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The morphine/heroin vaccine decreased the heroin-induced antinociceptive and reinforcing effects in three inbred strains mouse

dc.creatorBarbosa-Méndez, Susanaes_ES
dc.creatorMatus-Ortega, Mauraes_ES
dc.creatorHernández-Miramontes, Ricardoes_ES
dc.creatorSalazar-Juárez, Albertoes_ES
dc.date2021
dc.date.accessioned2024-07-30T18:38:52Z
dc.date.available2024-07-30T18:38:52Z
dc.date.issued2021
dc.identifierJC07IC21es_ES
dc.identifier.issn1567-5769
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8027
dc.identifier.urihttps://doi.org/10.1016/j.intimp.2021.107887
dc.descriptionClinical trials have indicated that a vaccine must be immunogenic in genetically diverse human populations and that immunogenicity and protective efficacy in animal models are two key indices required for the approval of a new vaccine. Additionally, the immune response (immunogenicity) and immunoprotection are dependent on the mouse strain. Therefore, the objective of the present study was to determine the immune response (immunogenicity) and the protective efficacy (behavioral response) in three inbred mouse strains immunized with the M6TT vaccine. Female BALB/c, C57Bl/6, and DBA/2 inbred mice were immunized with the M6-TT vaccine. A solid-phase antibody-capture ELISA was used to monitor antibody titer responses after each booster dose in vaccinated animals. The study used tail-flick testing to evaluate the antinociceptive effects induced by heroin. Additionally, heroin-induced locomotor activity and place preference were evaluated. The M6-TT vaccine was able to generate a specific antibody titer in the three inbred mouse strains evaluated. The antibodies reduced the antinociceptive effect of different doses of heroin. In addition, they decreased the heroin-induced locomotor activity and place preference. These findings suggest that the M6-TT vaccine generates a powerful immunogenic response capable of reducing the antinociceptive and reinforcing effects of heroin in different inbred mouse strains, which supports its possible future use in clinical trials in genetically diverse human populations.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation98:107887
dc.rightsAcceso Cerradoes_ES
dc.titleThe morphine/heroin vaccine decreased the heroin-induced antinociceptive and reinforcing effects in three inbred strains mousees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationSubdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, México DF 14370, Mexico
dc.contributor.emailazazel_vamp@yahoo.com.mx (A. Salazar-Juárez)
dc.relation.jnabreviadoINT IMMUNOPHARMACOL
dc.relation.journalInternational Immunopharmacology
dc.identifier.placePaíses Bajos
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1878-1705
dc.identifier.doihttps://doi.org/10.1016/j.intimp.2021.107887
dc.subject.kwActive vaccination
dc.subject.kwHeroin
dc.subject.kwAntibodies
dc.subject.kwM− TT vaccine
dc.subject.kwNociception, inbred mouse strain
dc.subject.kwLocomotor activity
dc.subject.kwPlace preference


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