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Pharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in mice

dc.creatorGonzález-Trujano, M. E.es_ES
dc.creatorUrbina-Trejo, E.es_ES
dc.creatorSantos-Valencia, F.es_ES
dc.creatorVillasana-Salazar, B.es_ES
dc.creatorCarmona-Aparicio, L.es_ES
dc.creatorMartínez-Vargas, D.es_ES
dc.date2021
dc.date.accessioned2024-06-20T20:07:41Z
dc.date.available2024-06-20T20:07:41Z
dc.date.issued2021
dc.identifierJC31NC21es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8010
dc.identifier.urihttps://doi.org/10.1016/j.jep.2021.113866
dc.descriptionEthnopharmacological relevance: Ruta chalepensis L. (Rutaceae) is used in traditional medicine to treat a wide variety of disorders such as rheumatism, fever, mental disorders, dropsy, neuralgia, menstrual problems, anxiety, and epilepsy. Aim of the study: To evaluate and compare the anticonvulsant properties of an aqueous extract and ethyl acetate (AcOEt) fraction of R. chalepensis on pentylenetetrazole (PTZ)-induced seizures and maximal electroshock (MES) test in mice, by analyzing behavior and electroencephalogram (EEG), as well as GABAA receptors involvement. Methods: The effect of an acute administration of different dosage of the aqueous extract (300 or 500 mg/kg) or AcOEt fraction (100, 300, 500 or 1000 mg/kg) of R. chalepensis was explored on two different models of acute seizure induction in mice, the PTZ and maximal electroshock (MES) tests. Behavioral and electrographic effects were quantified. Additionally, the possible involvement of the GABAA receptors was explored in the presence of picrotoxin (a non-competitive antagonist of the GABAA receptor). Results: AcOEt fraction of R. chalepensis was more efficient than aqueous extract to reduce the incidence of tonic-clonic seizures and mortality in a significant and dose-dependent manner in both the PTZ and MES tests. This anticonvulsant effect was not abolished in the presence of picrotoxin. The EEG spectral power analysis revealed that aqueous extract decreased alpha and beta power, while AcOEt fraction decreased alpha and gamma power confirming previous findings of its depressant effect in the central nervous system. It is important to mention that the highest dosage of the AcOEt (1000 mg/kg) produced a severe suppression or isoelectric EEG activity (EEG flattening), recognized as a comatose state, suggesting a neurotoxic effect at this dosage. Conclusion: Our data reinforce that depressant and anticonvulsant effects of R. chalepensis depend in part on the presence of constituents from medium polarity. We also found that anticonvulsant effect is not mediated by GABAA receptors. In addition, cautious is emphasized when high doses of this natural product are used in traditional medicine since it might produce neurotoxic effects.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation271:113866
dc.rightsAcceso Cerradoes_ES
dc.titlePharmacological and toxicological effects of Ruta chalepensis L. on experimentally induced seizures and electroencephalographic spectral power in micees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de La Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, 14370, Ciudad de México, Mexico
dc.contributor.emailevag@imp.edu.mx (M.E. Gonzalez-Trujano), eurbinat@gmail.com (E. Urbina-Trejo), psicfernandosv@gmail.com (F. Santos-Valencia), benvillasanasalazar@gmail.com (B. Villasana-Salazar), c_apariccio@yahoo.com.mx (L. Carmona-Aparicio), davmv@imp.edu.mx, davmv2@gmail.com (D. Martínez-Vargas)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.identifier.placeIrlanda
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2021.113866
dc.subject.kwAnticonvulsant
dc.subject.kwElectroencephalography
dc.subject.kwSpectral power analysis
dc.subject.kwMedicinal plants
dc.subject.kwRuta chalepensis L


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