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Calea zacatechichi Schltdl. (Compositae) produces anxiolytic- and antidepressant-like effects, and increases the hippocampal activity during REM sleep in rodents

dc.creatorMartinez-Mota, Lucíaes_ES
dc.creatorCruz-Tavera, Adriánes_ES
dc.creatorDorantes-Barrón, Ana Maríaes_ES
dc.creatorArrieta-Báez, Danieles_ES
dc.creatorRamírez-Salado, Ignacioes_ES
dc.creatorCruz-Aguilar, Manuel Alejandroes_ES
dc.creatorMayagoitia-Novales, Lilianes_ES
dc.creatorCassani, Juliaes_ES
dc.creatorEstrada-Reyes, Rosaes_ES
dc.date2021
dc.date.accessioned2024-06-19T19:02:41Z
dc.date.available2024-06-19T19:02:41Z
dc.date.issued2021
dc.identifierJC26NC21es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8005
dc.identifier.urihttps://doi.org/10.1016/j.jep.2020.113316
dc.descriptionEthnopharmacological relevance: Calea zacatechichi is a plant with an extensive popular and ritual use in Mexico. In healthy volunteers, it induces well-being and tranquility senses, and facilitates superficial stages of sleep. However, anxiolytic, and antidepressant-like effects and changes on the sleep-waking stages have not been explored. Aim: To determine anxiolytic and antidepressant-like effects of an aqueous extract of C. zacatechichi (CZ) in rodents and to analyze their effects on hippocampal activity in the rat sleep-waking cycle. Material and methods: CZ anxiolytic- and antidepressant-like effects were evaluated in several mice and rat behavioral paradigms. CZ effects on temporal distribution of sleep were described, and hippocampus EEG frequency patterns were analyzed during the sleep-waking cycle; absolute and relative powers were analyzed during Rapid Eye Movements (REM) and non-REM sleep stages. CZ chemical analysis was performed by UPLC-ESI-MS. Results: CZ produced specific and robust anxiolytic- and antidepressant-like effects in mice and rats, similar to those of prototypical drugs, at doses ranging from 0.5 to 50 mg/kg. CZ at 100 mg/kg produced visible mild sedative effects in rats, associated with a significant increase in Slow Wave Sleep episodes during a 6 h recording, and enhanced fast frequencies of hippocampus (gamma-band:31-50 Hz) during REM sleep. Conclusion: Results could support the well-being and tranquility senses reported by healthy consumers, and to explain the oneiric content during dreams and some improvements in cognitive processes described by consumers. Anxiolytic- and antidepressant-like effects of this species, reported for first time in this study could improve some aspects of mental health.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation265:113316
dc.rightsAcceso Cerradoes_ES
dc.titleCalea zacatechichi Schltdl. (Compositae) produces anxiolytic- and antidepressant-like effects, and increases the hippocampal activity during REM sleep in rodentses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370, Ciudad de México, Mexico
dc.contributor.emailrestrada@imp.edu.mx (R. Estrada-Reyes)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJ Ethnopharmacol
dc.identifier.placeIrlanda
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2020.113316
dc.subject.kwCalea zacatechichi
dc.subject.kwAnxiety
dc.subject.kwDepression
dc.subject.kwDreams
dc.subject.kwHippocampal gamma-band
dc.subject.kwBrain oscillations
dc.subject.kwSpectrum-EEG bands
dc.subject.kwClomipramine hydrochloride (PubChem CID: 4336361)
dc.subject.kwButorphanol (PubChem CID: 24892126)
dc.subject.kwDesipramine hydrochloride (PubChem CID: 65327)
dc.subject.kwDiazepam (PubChem CID: 3016)
dc.subject.kwFluoxetine (PubChem CID: 62857)


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