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EEG coherence and power spectra during REM sleep related to melatonin intake in mild-to-moderate Alzheimer's disease: a pilot study

dc.creatorCruz-Aguilar, Manuel Alejandroes_ES
dc.creatorRamírez-Salado, Ignacioes_ES
dc.creatorHernández-González, Mariselaes_ES
dc.creatorGuevara, Miguel Angeles_ES
dc.creatorRivera-García, Ana Paulaes_ES
dc.date2023
dc.date.accessioned2024-06-19T17:11:28Z
dc.date.available2024-06-19T17:11:28Z
dc.date.issued2023
dc.identifierJC24NC21es_ES
dc.identifier.issn0020-7454
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8003
dc.identifier.urihttps://doi.org/10.1080/00207454.2021.1928115
dc.descriptionIt has been reported that melatonin diminishes rapid eye movement (REM) sleep latency in patients with Alzheimer's disease (AD). Pharmacological studies suggest that melatonin promotes prompt sleep installation through interaction with GABA receptors, and that it is associated with acute suppression of neural electrical activity. Nevertheless, melatonin's effects on electroencephalographic (EEG) activity related to REM sleep onset in AD patients have not been analyzed. Thus, in this pilot study we analyzed the effects of melatonin on EEG activity during the first episode of REM sleep in eight patients treated with 5-mg of fast-release melatonin. During a single-blind, placebo-controlled study, polysomnographic recordings were obtained from frontal, central, temporal, and occipital scalp derivations. REM sleep latency, as well as the relative power (RP) and EEG coherences of six EEG bands, were compared between the placebo and melatonin conditions. Results showed that melatonin intake in AD patients decreased REM sleep onset, and that this was associated with lower RP and coherence of the β and γ EEG bands. The possibility that the inhibitory GABAergic pathways related to REM sleep generation are well-preserved in mild-to-moderate AD is discussed. We conclude that the short REM sleep onset related to melatonin intake in AD patients is associated with a significant decrease in both RP and EEG coherence, mainly in the fast frequencies.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherInforma Healthcarees_ES
dc.relation133(4):441-449
dc.rightsAcceso Cerradoes_ES
dc.titleEEG coherence and power spectra during REM sleep related to melatonin intake in mild-to-moderate Alzheimer's disease: a pilot studyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Cronobiología y Sueño, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz," Ciudad de México, CDMX, México
dc.contributor.emailmacrag@gmail.com (Manuel Alejandro Cruz-Aguilar)
dc.relation.jnabreviadoINT J NEUROSCI
dc.relation.journalInternational Journal of Neuroscience
dc.identifier.placeInglaterra
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1563-5279
dc.identifier.doi10.1080/00207454.2021.1928115
dc.subject.kwMelatonin
dc.subject.kwAlzheimer’s disease
dc.subject.kwREM sleep
dc.subject.kwGABA
dc.subject.kwEEG coherence


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