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Anticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in rats

dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorContreras-Murillo, Gerardoes_ES
dc.creatorLópez-Najera, Claudia Andreaes_ES
dc.creatorHidalgo-Flores, Fernando Josuées_ES
dc.creatorNavarrete-Castro, Andréses_ES
dc.creatorGamboa Sánchez, Concepciónes_ES
dc.creatorMagdaleno-Madrigal, Víctor Manueles_ES
dc.date2021
dc.date.accessioned2024-06-12T20:02:52Z
dc.date.available2024-06-12T20:02:52Z
dc.date.issued2021
dc.identifierJC23NC21es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8001
dc.identifier.urihttps://doi.org/10.1016/j.jep.2020.113299
dc.descriptionEthnopharmacological relevance: For many centuries, Mexican Valerian (Valeriana edulis ssp. procera) has been an important plant in folk medicine. It has been considered useful to control epilepsy; however, electroencephalographic evidence of its anticonvulsant activity is missing in literature. Aim of the study: In the present study, in situ electroencephalographic (EEG) analysis was performed along with administration of a crude ethanol extract of V. edulis and its valepotriate fraction on the pentylenetetrazole (PTZ)-induced convulsive behavior in rats. Materials and methods: Experiments were performed using male Wistar rats with nail-shaped electrodes implanted in the frontal and parietal cortices for EEG recording. All animals received a single dose of PTZ (35 mg/kg, i.p.) to test the anticonvulsant activity of V. edulis crude extract and valepotriate fraction (100 mg/kg, i.p.) 15 and/or 30 min after administration. EEG recordings were obtained from the cortices and were evaluated to assess ictal behavior over 60-75 min. Chromatographic analysis of the valepotriate fraction and in silico predictions of pharmacodynamic properties were also explored. The latency, frequency and duration of seizures evaluated using EEG recordings from the frontal and parietal cortices of rats showed significant changes demonstrating the inhibition of paroxystic activity. Results: The spectral analysis confirmed the reduction of excitatory activity induced by V. edulis extract, which was improved in the presence of the valepotriate fraction as compared to that induced by ethosuximide (a reference anticonvulsant drug). The presence of valepotriates such as: isodihydrovaltrate (18.99%), homovaltrate (13.51%), 10-acetoxy-valtrathydrin (4%) and valtrate (1.34%) was identified by chromatographic analysis. Whereas, not only GABAA receptor participation but also the cannabinoid CB2 receptor was found to be likely involved in the anticonvulsant mechanism of action after in silico prediction. Conclusions: Our data support the anticonvulsant properties attributed to this plant in folk medicine, due to the presence of valepotriates.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation265:113299
dc.rightsAcceso Cerradoes_ES
dc.titleAnticonvulsant activity of Valeriana edulis roots and valepotriates on the pentylenetetrazole-induced seizures in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Calz. México-Xochimilco No. 101 Col, San Lorenzo Huipulco, 14370, Ciudad de México, Mexico
dc.contributor.emailmaleno@imp.edu.mx, malenomad@gmail.com (V.M. Magdaleno-Madrigal)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.identifier.placeIrlanda
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2020.113299
dc.subject.kwAnticonvulsant
dc.subject.kwElectroencephalogram (EEG)
dc.subject.kwCentral nervous system
dc.subject.kwValeriana edulis ssp. procera
dc.subject.kwValerianaceae


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