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Effect of the morphine/heroin vaccine on opioid and non-opioid drug-induced antinociception in mice

dc.creatorBarbosa Méndez, Susanaes_ES
dc.creatorMatus-Ortega, Mauraes_ES
dc.creatorHernández Miramontes, Ricardoes_ES
dc.creatorSalazar-Juárez, Albertoes_ES
dc.date2021
dc.date.accessioned2024-06-12T19:04:47Z
dc.date.available2024-06-12T19:04:47Z
dc.date.issued2021
dc.identifierOE15IC21es_ES
dc.identifier.issn0014-2999
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7999
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2020.173718
dc.descriptionPain is a common symptom in patients with opioid use disorder (OUD), which increases synthetic and illicit synthetic opioid abuse and even fatalities due to opioid overdose. Many FDA-approved drugs are available for the treatment of OUD, however, the use of these medications is limited, mainly due to the development of various side effects. Active vaccination is a new therapeutic approach but the resulting antibodies may compromise the use and efficiency of opioid and non-opioid drugs. In this study, we evaluated whether the antibodies produced by the morphine/heroin vaccine (M-TT) would alter the antinociceptive effects of opioid and non-opioid drugs. Female Balb-c mice were immunized with the M-TT vaccine. A solid-phase antibody-capture ELISA was used for monitoring antibody titer responses after each booster dose in vaccinated animals, followed by tail-flick testing. This study found that the M-TT vaccine did not affect the antinociception induced by different doses of morphine or the ability of non-opioid and synthetic opioid drugs to decrease thermal pain. Moreover, the combination of vaccination and naloxone increased the time-course of morphine antagonism relative to either vaccination or naloxone alone. These results suggest that the antibody titers generated by the M-TT vaccine 1) are capable of reducing morphine-induced antinociception and 2) are selective enough not to alter antinociception induced by non-opioid or synthetic drugs. These characteristics support its potential as a treatment agent for patients with symptoms of pain comorbid to OUD.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherNorth Holland Pubes_ES
dc.relation15:891:173718
dc.rightsAcceso Cerradoes_ES
dc.titleEffect of the morphine/heroin vaccine on opioid and non-opioid drug-induced antinociception in micees_ES
dc.typeArticuloes_ES
dc.contributor.affiliationSubdirección de Investigaciones Clínicas. Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, México, DF, 14370. México
dc.contributor.emailazazel_vamp@yahoo.com.mx
dc.relation.jnabreviadoEUR J PHARMACOL
dc.relation.journalEuropean Journal of Pharmacology.
dc.identifier.placePaíses Bajos
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1879-0712
dc.identifier.doi10.1016/j.ejphar.2020.173718
dc.subject.kwActive vaccination
dc.subject.kwAntibodies
dc.subject.kwM-TT vaccine
dc.subject.kwMorphine
dc.subject.kwNociception


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