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Neo-clerodane diterpenic influence in the antinociceptive and anti-inflammatory properties of Salvia circinnata Cav

dc.creatorMoreno-Pérez, Fernandoes_ES
dc.creatorHernandez-Leon, Albertoes_ES
dc.creatorValle-Dorado, María Guadalupees_ES
dc.creatorCano-Martínez, Agustinaes_ES
dc.creatorNarváez-González, Fernandoes_ES
dc.creatorAguirre-Hernández, Evaes_ES
dc.creatorSalgado-Ceballos, Hermelindaes_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.date2021
dc.date.accessioned2024-06-10T20:05:57Z
dc.date.available2024-06-10T20:05:57Z
dc.date.issued2021
dc.identifierJC21NC21es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7997
dc.identifier.urihttps://doi.org/10.1016/j.jep.2020.113550
dc.descriptionEthnopharmacological relevance: Mexico is considered an ancestral center of diversity of Salvia species, however many of them lack scientific information. Salvia circinnata Cav. (syn. Salvia amarissima Ortega) is an endemic species used in traditional medicine to treat disorders attributed to a cold state like anxiety in the central nervous system, as well as gastrointestinal ailments and pain relief. Aim of the study: To give preclinical evidence about the pharmacological properties of this species by investigating its antinociceptive and anti-inflammatory effects, the chemical nature of at least one metabolite, and a possible mechanism of action and adverse effects, using different experimental models of pain. Material and methods: Different crude extracts of Salvia circinnata Cav. aerial parts were prepared using increasing polarity and evaluated in the formalin test in mice. This screening allowed to select and evaluate an ethyl acetate extract (EtOAc), as the most bioactive extract, and a metabolite. Antinociceptive and anti-inflammatory activities were confirmed using the plantar test and carrageenan-induced edema. The antinociceptive effects of the extracts were compared to that observed with morphine (1 mg/kg), tramadol (20 mg/kg) or indomethacin (20 mg/kg) as reference drugs. Participation of opioids and TRPV1 receptors was investigated, as well as acute toxicity and adverse effects of sedation and gastric damage. Results: EtOAc (0.1-10 mg/kg) of S. circinnata Cav. showed a dose-dependent and significant antinociceptive activity, associated in part with the presence of a neo-clerodane glycoside amarisolide A (0.01-1 mg/kg), in the neurogenic and inflammatory phases of the formalin test. Central action of both treatments was corroborated in the plantar test, whereas anti-inflammatory effects were confirmed with the extract (1 and 10 mg/kg) and amarisolide A (1 mg/kg) in the carrageenan-induced edema test. An opioid mechanism in both treatments, and the TRPV1 receptor modulation in the extract were involved. No acute toxicity and adverse effects were noticed with the extract and pure compound in comparison to the reference drugs. Conclusion: These results provide preclinical evidence of the ethnopharmacological antinociceptive S. circinnata Cav. properties, in which the neo-clerodane diterpene glycoside amarisolide A was partially responsible involving the participation of the opioid receptors, while TRPV1 receptor modulation was implicated in the anti-inflammatory activity may be because of the presence of other constituents. This information supports the use of this species in folk medicine for pain therapy.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation268:113550
dc.rightsAcceso Cerradoes_ES
dc.titleNeo-clerodane diterpenic influence in the antinociceptive and anti-inflammatory properties of Salvia circinnata Caves_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales de La Dirección de Investigaciones en Neurociencias Del Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Ciudad de México, Mexico
dc.contributor.emailaddresses: mmspoodles@gmail.com (M.-P. Fernando), albertoh-leon@hotmail.com (H.-L. Alberto), lvalle-59@hotmail.com (V.-D. María Guadalupe), cmamx2002@yahoo.com.mx (C.-M. Agustina), drnarvaezg@hotmail.com (N.-G. Fernando), eva_aguirre@ciencias.unam.mx (A.-H. Eva), melisalce@yahoo.com (S.-C. Hermelinda), evag@imp.edu.mx (G.-T. María Eva)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.identifier.placeIrlanda
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2020.113550
dc.subject.kwAmarisolide A
dc.subject.kwFolk medicine
dc.subject.kwPain
dc.subject.kwSalvia amarissima
dc.subject.kwTRPV1 receptors


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