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Mirtazapine decreased induction and expression of cocaine + nicotine-induced locomotor sensitisation in rats

dc.creatorBarbosa Méndez, Susanaes_ES
dc.creatorSalazar-Juárez, Albertoes_ES
dc.date2021
dc.date.accessioned2024-06-06T15:19:31Z
dc.date.available2024-06-06T15:19:31Z
dc.date.issued2021
dc.identifierOE14IC21es_ES
dc.identifier.issn1562-2975
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7995
dc.identifier.urihttps://doi.org/10.1080/15622975.2019.1620967
dc.descriptionConcurrent abuse of cocaine and nicotine is considered a public health problem. To date, no effective therapy has been known to reduce the reinforcing effects of concurrent use of cocaine and nicotine. Mirtazapine, an antagonist of the α2-adrenoceptor and the 5-HT2A/C and the 5-HT3 receptors has proven effective in reducing the cocaine, nicotine and methamphetamine behavioural effects in humans and animals. Our study evaluated the effect of mirtazapine on enhancing locomotor activity during the induction and expression of locomotor sensitisation induced by a cocaine + nicotine mixture.Methods: Wistar rats were dosed with cocaine, nicotine or cocaine + nicotine combination. Mirtazapine (30 mg/kg, i.p.) was administered during the extinction phase.Results: Mirtazapine decreased cocaine + nicotine-induced locomotor activity and induction and expression of locomotor sensitisation. In addition, we found that co-administration of mecamylamine and mirtazapine significantly enhanced the effect of mirtazapine on cocaine + nicotine-induced locomotor activity during induction and expression of behavioural sensitisation.Conclusions: Our results suggest that mirtazapine demonstrated efficacy in decreasing the psycho-stimulant effects of concurrent use of cocaine and nicotine.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherInforma Healthcarees_ES
dc.relation21(8):595-611
dc.rightsAcceso Cerradoes_ES
dc.titleMirtazapine decreased induction and expression of cocaine + nicotine-induced locomotor sensitisation in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationSubdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología Conductual, Microcirugía, y Terapéutica Experimental, Instituto Nacional de Psiquiatría, Ciudad de México, 14370, México.
dc.relation.jnabreviadoWORLD J BIOL PSYCHIATRY
dc.relation.journalWorld Journal of Biological Psychiatry
dc.identifier.placeInglaterra
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1814-1412
dc.identifier.doi10.1080/15622975.2019.1620967
dc.subject.kwNicotine
dc.subject.kwCocaine
dc.subject.kwLocomotor sensitisation
dc.subject.kwMecamylamine
dc.subject.kwMirtazapine


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