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Evaluation of the anticonvulsant and neuroprotective effect of intracerebral administration of growth hormone in rats

dc.creatorZamora-Belloa, I.es_ES
dc.creatorMartínez, A.es_ES
dc.creatorBeltrán-Parrazal, L.es_ES
dc.creatorSantiago-Roque, I.es_ES
dc.creatorJuárez-Aguilar, E.es_ES
dc.creatorLópez-Meraz, M. L.es_ES
dc.date2021
dc.date.accessioned2024-06-05T20:48:28Z
dc.date.available2024-06-05T20:48:28Z
dc.date.issued2021
dc.identifierJC19NC21es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7994
dc.identifier.urihttps://doi.org/10.1016/j.nrl.2021.03.010
dc.descriptionIntroduction: The growth hormone (GH) has been reported as a crucial neuronal survival factor in the hippocampus against insults of diverse nature. Status epilepticus (SE) is a prolonged seizure that produces extensive neuronal cell death. The goal of this study was to evaluate the effect of intracerebroventricular administration of GH on seizure severity and SE-induced hippocampal neurodegeneration. Methodology: Adult male rats were implanted with a guide cannula in the left ventricle and different amounts of GH (70, 120 or 220ng/3μl) were microinjected for 5 days; artificial cerebrospinal fluid was used as the vehicle. Seizures were induced by the lithium-pilocarpine model (3mEq/kg LiCl and 30mg/kg pilocarpine hydrochloride) one day after the last GH administration. Neuronal injury was assessed by Fluoro-Jade B (F-JB) staining. Results: Rats injected with 120ng of GH did not had SE after 30mg/kg pilocarpine, they required a higher number of pilocarpine injections to develop SE than the rats pretreated with the vehicle, 70ng or 220ng GH. Prefrontal and parietal cortex EEG recordings confirmed that latency to generalized seizures and SE was also significantly higher in the 120ng group when compared with all the experimental groups. FJ-B positive cells were detected in the hippocampus after SE in all rats, and no significant differences in the number of F-JB cells in the CA1 area and the hilus was observed between experimental groups. Conclusion: Our results indicate that, although GH has an anticonvulsive effect in the lithium-pilocarpine model of SE, it does not exert hippocampal neuroprotection after SE.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation39(1):1-9
dc.rightsAcceso Cerradoes_ES
dc.titleEvaluation of the anticonvulsant and neuroprotective effect of intracerebral administration of growth hormone in ratses_ES
dc.title.alternativeEvaluación del efecto anticonvulsivante y neuroprotector de la administración intracerebral de la hormona de crecimiento en ratas
dc.typeArtículoes_ES
dc.contributor.affiliationCentro de Investigaciones Cerebrales, Universidad Veracruzana, Médicos y Odontólogos s/n, Col. Unidad del Bosque Xalapa, Veracruz C.P. 91010, Mexico
dc.contributor.emailleonorlopez@uv.mx(M.L.López-Meraz)
dc.relation.jnabreviadoNEUROLOGIA
dc.relation.journalNeurologia
dc.identifier.placeEspaña
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2173-5808
dc.identifier.doi10.1016/j.nrl.2021.03.010
dc.subject.kwGrowthhormone
dc.subject.kwStatusepilepticus
dc.subject.kwNeurodegeneration
dc.subject.kwPilocarpine


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