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White matter abnormalities in late onset first episode mania: a diffusion tensor imaging study

dc.creatorRamírez-Bermudez, Jesuses_ES
dc.creatorMarrufo-Melendez, Oscares_ES
dc.creatorBerlanga-Flores, Ceciliaes_ES
dc.creatorGuadamuz, Adiliaes_ES
dc.creatorAtriano, Carmenes_ES
dc.creatorCarrillo-Mezo, Rogeres_ES
dc.creatorAlvarado, Patriciaes_ES
dc.creatorFavila, Rafaeles_ES
dc.creatorTaboada, Jesuses_ES
dc.creatorRios, Camiloes_ES
dc.creatorYoldi-Negrete, Mariaes_ES
dc.creatorRuiz-Garcia, Ramiroes_ES
dc.creatorTohen, Mauricioes_ES
dc.date2021
dc.date.accessioned2024-06-05T19:27:02Z
dc.date.available2024-06-05T19:27:02Z
dc.date.issued2021
dc.identifierOE13IC21es_ES
dc.identifier.issn1064-7481
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7993
dc.identifier.urihttps://doi.org/10.1016/j.jagp.2021.03.007
dc.descriptionA first manic episode after 50 years of age is uncommon. Late Onset Mania might be indicative of abnormalities in white matter, probably related to vascular, degenerative, or inflammatory processes. Objective To determine if patients with late onset mania have reduced white matter integrity according to Magnetic Resonance Diffusion Tensor Imaging (DTI) and structural MRI. Methods Twenty-two patients with late onset mania (>50 years old) and 22 age-paired healthy subjects were included in the study. Fractional anisotropy (FA) was used as a quantitative measure of white matter integrity. Fazekas scale was assessed also to measure white matter abnormalities in the FLAIR sequence. The Frontal Assessment Battery, COGNISTAT and Trail making test A and B were used as cognitive measurements. Results According to DTI, commissural connections (left corpus callosum), and limbic connections (right and left uncinate fasciculus) were different between the patients and the comparison group. Fractional anisotropy values in the left corpus callosum showed significant correlations with neuropsychological measures, and with the Fazekas scale score. According to Fazekas scale, a pathological score in the FLAIR sequence was significantly more frequent in the patients as compared to the comparison group. Conclusions Patients with first episode mania in late life have relevant white matter abnormalities not explained by age, affecting interhemispheric and fronto-limbic networks probably related to executive functioning and emotional processing, at the level of the corpus callosum and the uncinate fasciculus. The etiology of this white matter loss of integrity in patients with late-onset mania is yet to be explored.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation29(12):1225-1236
dc.titleWhite matter abnormalities in late onset first episode mania: a diffusion tensor imaging studyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationNational Autonomous University of Mexico, School of Medicine; National Institute of Neurology and Neurosurgery, Neuropsychiatry
dc.contributor.emailjesusramirezb@yahoo.com.mx
dc.relation.jnabreviadoAM J GERIATR PSYCHIATRY
dc.relation.journalAmerican Journal of Geriatric Psychiatry
dc.identifier.placeInglaterra
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1545-7214
dc.identifier.doi10.1016/j.jagp.2021.03.007
dc.subject.kwMania
dc.subject.kwBipolar disorder
dc.subject.kwWhite matter
dc.subject.kwLimbic system
dc.subject.kwCorpus callosum
dc.subject.kwNeuropsychiatry


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