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Bertholletia excelsa seeds reduce anxiety-like behavior, lipids, and overweight in mice

dc.creatorFrausto-González, Oswaldoes_ES
dc.creatorBautista, Claudia J.es_ES
dc.creatorNarváez-González, Fernandoes_ES
dc.creatorHernandez-Leon, Albertoes_ES
dc.creatorEstrada-Camarena, Erikaes_ES
dc.creatorRivero-Cruz, Faustoes_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.date2021
dc.date.accessioned2024-06-03T17:26:04Z
dc.date.available2024-06-03T17:26:04Z
dc.date.issued2021
dc.identifierJC15NC21es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7988
dc.identifier.urihttps://doi.org/10.3390/molecules26113212
dc.descriptionOverweight, obesity, and psychiatric disorders are serious health problems. To evidence the anxiolytic-like effects and lipid reduction in mice receiving a high-calorie diet and Bertholletia excelsa seeds in a nonpolar extract (SBHX, 30 and 300 mg/kg), animals were assessed in open-field, hole-board, and elevated plus-maze tests. SBHX (3 and 10 mg/kg) potentiated the pentobarbital-induced hypnosis. Chronic administration of SBHX for 40 days was given to mice fed with a hypercaloric diet to determine the relationship between water and food intake vs. changes in body weight. Testes, epididymal white adipose tissue (eWAT), and liver were dissected to analyze fat content, triglycerides, cholesterol, and histological effects after administering the hypercaloric diet and SBHX. Fatty acids, such as palmitoleic acid (0.14%), palmitic acid (21.42%), linoleic acid (11.02%), oleic acid (59.97%), and stearic acid (7.44%), were identified as constituents of SBHX, producing significant anxiolytic-like effects and preventing body-weight gain in mice receiving the hypercaloric diet without altering their water or food consumption. There was also a lipid-lowering effect on the testicular tissue and eWAT and a reduction of adipocyte area in eWAT. Our data evidence beneficial properties of B. excelsa seeds influencing global health concerns such as obesity and anxiety.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation26(11): 3212
dc.rightsAcceso Cerradoes_ES
dc.titleBertholletia excelsa seeds reduce anxiety-like behavior, lipids, and overweight in micees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, 14370 Mexico City, Mexico
dc.contributor.emailestrada@imp.edu.mx (E.E.-C.); evag@imp.edu.mx (M.E.G.-T.)
dc.relation.jnabreviadoMOLECULES
dc.relation.journalMolecules
dc.identifier.placeSuiza
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1420-3049
dc.identifier.doi10.3390/molecules26113212
dc.subject.kwAnxiety
dc.subject.kwBertholletia excelsa
dc.subject.kwCentral nervous system
dc.subject.kwLipids
dc.subject.kwOverweight


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