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Short daily exposure to environmental enrichment, fluoxetine, or their combination reverses deterioration of the coat and anhedonia behaviors with differential effects on hippocampal neurogenesis in chronically stressed mice

dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.creatorVega-Rivera, Nelly Maritzaes_ES
dc.creatorMeneses-San Juan, Davides_ES
dc.creatorOrtiz-López, Leonardoes_ES
dc.creatorEstrada-Camarena, Erika Montserrates_ES
dc.creatorFlores-Ramos, Mónicaes_ES
dc.date2021
dc.date.accessioned2024-05-31T16:44:44Z
dc.date.available2024-05-31T16:44:44Z
dc.date.issued2021
dc.identifierJC11NC21es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7983
dc.identifier.urihttps://doi.org/10.3390/ijms222010976
dc.descriptionDepression is a neuropsychiatric disorder with a high impact on the worldwide population. To overcome depression, antidepressant drugs are the first line of treatment. However, pre-clinical studies have pointed out that antidepressants are not entirely efficacious and that the quality of the living environment after stress cessation may play a relevant role in increasing their efficacy. As it is unknown whether a short daily exposure to environmental enrichment during chronic stress and antidepressant treatment will be more effective than just the pharmacological treatment, this study analyzed the effects of fluoxetine, environmental enrichment, and their combination on depressive-associated behavior. Additionally, we investigated hippocampal neurogenesis in mice exposed to chronic mild stress. Our results indicate that fluoxetine reversed anhedonia. Besides, fluoxetine reversed the decrement of some events of the hippocampal neurogenic process caused by chronic mild stress. Conversely, short daily exposure to environmental enrichment changed the deterioration of the coat and anhedonia. Although, this environmental intervention did not produce significant changes in the neurogenic process affected by chronic mild stress, fluoxetine plus environmental enrichment showed similar effects to those caused by environmental enrichment to reverse depressive-like behaviors. Like fluoxetine, the combination reversed the declining number of Ki67, doublecortin, calretinin cells and mature newborn neurons. Finally, this study suggests that short daily exposure to environmental enrichment improves the effects of fluoxetine to reverse the deterioration of the coat and anhedonia in chronically stressed mice. In addition, the combination of fluoxetine with environmental enrichment produces more significant effects than those caused by fluoxetine alone on some events of the neurogenic process. Thus, environmental enrichment improves the benefits of pharmacological treatment by mechanisms that need to be clarified.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation22(20):10976
dc.rightsAcceso Cerradoes_ES
dc.titleShort daily exposure to environmental enrichment, fluoxetine, or their combination reverses deterioration of the coat and anhedonia behaviors with differential effects on hippocampal neurogenesis in chronically stressed micees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio of Neurogenesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calzada México-Xochimilco 101, Mexico City C.P. 14370, Mexico
dc.contributor.emailgbernabe@imp.edu.mx
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.identifier.placeSuiza
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1422-0067
dc.identifier.doi10.3390/ijms222010976
dc.subject.kwAdult neurogenesis
dc.subject.kwHippocampus
dc.subject.kwDepression
dc.subject.kwChronic mild stress
dc.subject.kwEnvironmental enrichment
dc.subject.kwFluoxetine


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