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Toxoplasma gondii and psychopathology: latent infection is associated with interpersonal sensitivity, psychoticism, and higher testosterone levels in men, but not in women

dc.creatorBorráz-León, Javier I.es_ES
dc.creatorRantala, Markus J.es_ES
dc.creatorLuoto, Severies_ES
dc.creatorKrams, Indrikises_ES
dc.creatorContreras-Garduño, Jorgees_ES
dc.creatorCerda-Molina, Ana Liliaes_ES
dc.creatorKrama, Tatjanaes_ES
dc.date2021
dc.date.accessioned2024-05-30T19:16:13Z
dc.date.available2024-05-30T19:16:13Z
dc.date.issued2021
dc.identifierJC09NC21es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7981
dc.identifier.urihttps://doi.org/10.1007/s40750-020-00160-2
dc.descriptionObjective The ability of parasites to hijack the nervous system, manipulating the host’s physiology and behavior in ways that enhance the parasite’s fitness while damaging host fitness, is a topic of ongoing research interest in evolutionary biology, but is largely overlooked in mental health research. Nevertheless, recent evidence has shown that Toxoplasma gondii infection can change host testosterone levels and influence the development of some psychiatric disorders. Here, we tested this hypothesis in a mixed sample of 213 non-clinical subjects. Methods Participants (nmales = 108, nfemales = 105) provided 5 ml of blood to quantify testosterone levels and Toxoplasma gondii antibodies. The Symptom Checklist-90- Revised was used to assess psychopathological symptoms. Results The results showed that Toxoplasma-infected men had higher testosterone levels and scored higher in Interpersonal Sensitivity and Psychoticism symptoms than non-infected men. Toxoplasma-infected women did not differ from control women. Conclusions Framed in an evolutionary framework, the findings suggest that the elevated testosterone levels and the expression of psychopathological symptoms can be seen as the result of the manipulation exerted by Toxoplasma gondii either to reach its definitive host or to increase its spread. Future research can benefit from integrating insights from evolutionary biology and parasite-host interactions with physiology, immunology, and mental health to develop a better understanding of mental health etiology.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherSpringer Naturees_ES
dc.relation7:28-42
dc.rightsAcceso Cerradoes_ES
dc.titleToxoplasma gondii and psychopathology: latent infection is associated with interpersonal sensitivity, psychoticism, and higher testosterone levels in men, but not in womenes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartment of Biology, University of Turku, Turku, Finland
dc.contributor.emailjibole@utu.fi; borraz@comunidad.unam.mx (Javier I. Borráz-León)
dc.relation.jnabreviadoADAPT HUMAN BEHAV PHYSIOL
dc.relation.journalAdaptive Human Behavior and Physiology
dc.identifier.placeSuiza
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2198-7335
dc.identifier.doi10.1007/s40750-020-00160-2
dc.subject.kwToxoplasmosis
dc.subject.kwParasites
dc.subject.kwSteroid hormones
dc.subject.kwMental health
dc.subject.kwEvolutionary theory


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