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Quercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in rats

dc.creatorVentura-Martínez, Rosaes_ES
dc.creatorDéciga-Campos, Myrnaes_ES
dc.creatorBustamante-Marquina, Aracelies_ES
dc.creatorÁngeles-López, Guadalupe Estheres_ES
dc.creatorAviles-Herrera, Josées_ES
dc.creatorGonzález-Trujano, Maria Evaes_ES
dc.creatorNavarrete-Vázquez, Gabrieles_ES
dc.date2021
dc.date.accessioned2024-05-29T17:39:43Z
dc.date.available2024-05-29T17:39:43Z
dc.date.issued2021
dc.identifierJC06NC21es_ES
dc.identifier.issn0022-3573
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7978
dc.identifier.urihttps://doi.org/10.1093/jpp/rgab093
dc.descriptionObjective: To analyse the antinociceptive interaction between quercetin (QUER) and diclofenac (DIC) in experimental arthritic gout-pain. Methods: The antinociceptive effect of DIC and QUER alone and in combination were evaluated using an arthritic gout-pain model. Pain was induced through intra-articular administration of uric acid in the rats and the treatments were administered 2 h later. Additionally, the cyclooxygenase (COX) activity was determined in rats treated with DIC, QUER and their combination. Key findings: DIC induced a maximal effect of 69.7 ± 2.7% with 3.1 mg/kg; whereas QUER only produced 17.6 ± 2.6% with the maximal dose (316 mg/kg). Ten of twelve DIC + QUER combinations showed a lesser antinociceptive effect than DIC alone did (P < 0.05). Moreover, DIC reduced total-COX (70.4 ± 1.3 versus 52.4 ± 1.8 and 77.4 ± 9.0 versus 56.1 ± 1.3, P < 0.05) and COX-2 (60.1 ± 1.0 versus 42.4 ± 1.8 and 58.1 ± 2.4 versus 48.7 ± 1.3, P < 0.05) activity after 1 and 3 h, respectively. Nevertheless, only the COX-2 activity induced by DIC was prevented in the presence of QUER (63.2 ± 3.0 versus 60.1 ± 1.0 and 56.6 ± 1.3 versus 58.1 ± 2.4 at 1 and 3 h, respectively). Conclusions: All these data demonstrated that the simultaneous administration of QUER + DIC produces an unfavorable interaction on the antinociceptive effect of DIC. Therefore, this combination might not be recommendable to relieve arthritic gout-pain.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relation73(10):1310-1318
dc.rightsAcceso Cerradoes_ES
dc.titleQuercetin decreases the antinociceptive effect of diclofenac in an arthritic gout-pain model in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad de México, México.
dc.contributor.emailrventuram7@hotmail.com (Rosa Ventura-Martínez)
dc.relation.jnabreviadoJ PHARM PHARMACOL
dc.relation.journalJournal of Pharmacy and Pharmacology
dc.identifier.placeInglaterra
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2042-7158
dc.identifier.doi10.1093/jpp/rgab093
dc.subject.kwDiclofenac
dc.subject.kwQuercetin
dc.subject.kwPharmacological interaction
dc.subject.kwAntagonist effect
dc.subject.kwAntinociceptive effect


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