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Properties and differential expression of H+ receptors in dorsal root ganglia: is a labeled-line coding for acid nociception possible?

dc.creatorPáez, Omares_ES
dc.creatorSegura-Chama, Pedroes_ES
dc.creatorAlmanza, Angélicaes_ES
dc.creatorPellicer, Franciscoes_ES
dc.creatorMercado, Franciscoes_ES
dc.date2021
dc.date.accessioned2024-05-28T20:34:17Z
dc.date.available2024-05-28T20:34:17Z
dc.date.issued2021
dc.identifierJC04NC21es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7976
dc.identifier.urihttps://doi.org/10.3389/fphys.2021.733267
dc.descriptionPain by chemical irritants is one of the less well-described aspects of nociception. The acidic substance is the paradigm of the chemical noxious compound. An acidic insult on cutaneous, subcutaneous and muscle tissue results in pain sensation. Acid (or H+) has at least two main receptor channels in dorsal root ganglia (DRG) nociceptors: the heat receptor transient receptor potential vanilloid 1 (TRPV1) and the acid-sensing ionic channels (ASICs). TRPV1 is a low-sensitivity H+ receptor, whereas ASIC channels display a higher H+ sensitivity of at least one order of magnitude. In this review, we first describe the functional and structural characteristics of these and other H+-receptor candidates and the biophysics of their responses to low pH. Additionally, we compile reports of the expression of these H+-receptors (and other possible complementary proteins) within the DRG and compare these data with mRNA expression profiles from single-cell sequencing datasets for ASIC3, ASIC1, transient receptor potential Ankiryn subtype 1 (TRPA1) and TRPV1. We show that few nociceptor subpopulations (discriminated by unbiased classifications) combine acid-sensitive channels. This comparative review is presented in light of the accumulating evidence for labeled-line coding for most noxious sensory stimuli.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.relation12: 733267
dc.rightsAcceso Cerradoes_ES
dc.titleProperties and differential expression of H+ receptors in dorsal root ganglia: is a labeled-line coding for acid nociception possible?es_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Fisiología Celular, Dirección de Investigaciones en Nuerociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
dc.contributor.emailfmercado@imp.edu.mx (Francisco Mercado)
dc.relation.jnabreviadoFRONT PHYSIOL
dc.relation.journalFrontiers in Physiology
dc.identifier.placeSuiza
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1664-042X
dc.identifier.doi10.3389/fphys.2021.733267
dc.subject.kwProton
dc.subject.kwNociceptor
dc.subject.kwPain
dc.subject.kwAcid
dc.subject.kwASIC
dc.subject.kwTRP channels
dc.subject.kwDRG


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