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Increased survival in puppies affected by Canine Parvovirus type II using an immunomodulator as a therapeutic aid

dc.creatorMuñoz, Adriana I.es_ES
dc.creatorVallejo-Castillo, Luises_ES
dc.creatorFragozo, Anaes_ES
dc.creatorVázquez-Leyva, Saides_ES
dc.creatorPavón, Lenines_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorSoria-Castro, Rodolfoes_ES
dc.creatorMellado-Sánchez, Gabrielaes_ES
dc.creatorCobos-Marin, Lauraes_ES
dc.creatorPérez-Tapia, Sonia Mayra
dc.date2021
dc.date.accessioned2024-05-28T19:24:23Z
dc.date.available2024-05-28T19:24:23Z
dc.date.issued2021
dc.identifierJC03NC21es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7975
dc.identifier.urihttps://doi.org/10.1038/s41598-021-99357-y
dc.descriptionCanine parvovirus type II (CPV-2) infection induces canine parvoviral enteritis (CPE), which in turn promotes sepsis and systemic inflammatory response syndrome (SIRS). Mortality in this disease is usually registered within 48-72 h post-hospitalization, the critical period of the illness. It has been recently described that the use of an immunomodulator, whose major component is monomeric ubiquitin (mUb) without the last two glycine residues (Ub∆GG), in pediatric human patients with sepsis augments survival. It is known that CXCR4 is the cell receptor of extracellular ubiquitin in humans. This work aimed to explore the effect of one immunomodulator (human Dialyzable Leukocyte Extract-hDLE) as a therapeutic auxiliary in puppies with sepsis and SIRS induced by CPE. We studied two groups of puppies with CPV-2 infection confirmed by polymerase chain reaction. The first group received conventional treatment (CT) and vehicle (V), while the second group received CT plus the immunomodulator (I). We assessed both groups' survival, clinical condition, number of erythrocytes, neutrophils, and lymphocytes during the hospitalization period. In addition, hematocrit, hemoglobin, plasma proteins and cortisol values, as well as norepinephrine/epinephrine and serotonin concentration were determined. Puppies treated with CT + I showed 81% survival, mild clinical signs, and a significant decrease in circulating neutrophils and lymphocytes in the critical period of the treatment. In contrast, the CT + V group presented a survival of 42%, severe clinical status, and no improvement of the parameters evaluated in the critical period of the disease. We determined in silico that human Ub∆GG can bind to dog CXCR4. In conclusion, the administration of a human immunomodulator (0.5 mg/day × 5 days) to puppies with CPE under six months of age reduces the severity of clinical signs, increases survival, and modulates inflammatory cell parameters. Further studies are necessary to take full advantage of these clinical findings, which might be mediated by the human Ub∆GG to canine CXCR4 interaction.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relation11(1):19864
dc.rightsAcceso Cerradoes_ES
dc.titleIncreased survival in puppies affected by Canine Parvovirus type II using an immunomodulator as a therapeutic aides_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Inmunología. Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional (IPN), Prolongación de Carpio y Plan de Ayala S/N, Col. Santo Tomás, Alcaldía Miguel Hidalgo, 11340, CDMX, México
dc.contributor.emaillkuriaki@imp.edu.mx; sperezt@ipn.mx
dc.relation.jnabreviadoSCI REP
dc.relation.journalScientific Reports
dc.identifier.placeInglaterra
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2045-2322
dc.identifier.doi10.1038/s41598-021-99357-y


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