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Synergistic immune and antinociceptive effects induced from the combination of two different vaccines against morphine/heroin in mouse

dc.creatorBarbosa-Mendez, Susanaes_ES
dc.creatorMatus-Ortega, Mauraes_ES
dc.creatorHernandez-Miramontes, Ricardoes_ES
dc.creatorSalazar-Juárez, Albertoes_ES
dc.date2021
dc.date.accessioned2024-04-29T15:26:43Z
dc.date.available2024-04-29T15:26:43Z
dc.date.issued2021
dc.identifierOE08IC21es_ES
dc.identifier.issn2164-5515
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7957
dc.identifier.urihttps://doi.org/10.1080/21645515.2021.1935171
dc.descriptionAnimal studies have reported the use of different opioid-vaccine formulations with relative success These studies have suggested that new opioid-vaccine formulations are required, which are capable of triggering a robust humoral response. One strategy that has been used is the co-administration of two or more vaccines with different but complementary properties, which are capable of generating a robust immune response. We have developed two formulations of opioid-vaccine, the M6-TT, and M3-TT, which generate a robust immune response capable of recognizing heroin and morphine. In this work, we evaluate the combination of two vaccine formulations, which we call the M3/6-TT vaccine, to elicit a robust immune response and protection against heroin and morphine. Balb/c mice were immunized simultaneously with M6-TT vaccine and with M3-TT vaccine. A solid-phase antibody-capture ELISA was used for monitoring antibody titer responses after each booster dose in vaccinated animals. The study used tail-flick and hot-plate testing to evaluate the antinociceptive effects induced by heroin or morphine. Immunization with M3-TT and M6-TT vaccine elicits a robust immune response with an antibody titer of 1: 590 000 able to recognize heroin and morphine. These antibodies are capable of reducing the antinociceptive effects induced by doses of up to 40 mg/Kg. of morphine or 10 mg/kg of heroin. This suggests that the combination of two vaccine formulations that generate antibodies with different but complementary characteristics would be a new therapeutic strategy aimed at reducing drug relapses.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francises_ES
dc.relation17(10):3515-3528
dc.rightsAcceso Cerradoes_ES
dc.titleSynergistic immune and antinociceptive effects induced from the combination of two different vaccines against morphine/heroin in mousees_ES
dc.typeArticuloes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, México, México.
dc.relation.jnabreviadoHUM VACCIN IMMUNOTHER
dc.relation.journalHuman Vaccines & Immunotherapeutics.
dc.identifier.placeEstados Unidos
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2164-554X
dc.identifier.doi10.1080/21645515.2021.1935171
dc.subject.kwOpioid-drugs
dc.subject.kwVaccine
dc.subject.kwActive vaccination
dc.subject.kwAntibodies
dc.subject.kwHeroin
dc.subject.kwMorphine


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