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Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats

dc.creatorBarbosa-Méndez, Susanaes_ES
dc.creatorLópez-Morado, Casandraes_ES
dc.creatorSalazar-Juárez, Albertoes_ES
dc.date2021
dc.date.accessioned2024-04-03T18:06:14Z
dc.date.available2024-04-03T18:06:14Z
dc.date.issued2021
dc.identifierOE02IC2021es_ES
dc.identifier.issn0091-3057
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7934
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2021.173237
dc.descriptionSeveral studies have reported that mirtazapine attenuated the induction and expression of cocaine-induced locomotor sensitization. Animals placed in enriched housing environments have shown a decrease in cocaine-induced locomotor activity and sensitization. In addition, it has been suggested that a pharmacological treatment combined with a behavioral intervention increases the efficacy of the former. Thus, the objective of this study was to determine if dosing of mirtazapine in an enriched housing environment enhanced the mirtazapine-induced decrease on the induction and expression of cocaine-induced locomotor sensitization. Wistar male rats were dosed with cocaine (10 mg/kg, i.p.). During the drug-withdrawal phase, mirtazapine (30 mg/kg, i.p.) was administered under standard and enriched housing environmental conditions. The environmental enrichment consisted of housing the animals in enclosures with plastic toys, tunnels, and running wheels. After each administration, locomotor activity for each animal was recorded for 30 min. The study found that treatment with mirtazapine in an enriched housing environment produced an enhanced and persistent attenuation of the induction and expression of cocaine-induced locomotor sensitization. Additionally, it reduced the duration of cocaine-induced locomotor activity in the expression phase of locomotor sensitization. Dosing of mirtazapine in an enriched housing environment enhanced the effectiveness of mirtazapine to decrease cocaine-induced locomotor sensitization. This suggests the potential use of enriched environments to enhance the effect of mirtazapine.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation208:173237
dc.rightsAcceso Cerradoes_ES
dc.titleMirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationSubdirección de Investigaciones Clínicas, Laboratorio de Neurofarmacología Conductual, Microcirugía y Terapéutica Experimental, Instituto Nacional de Psiquiatría, Ciudad de México 14370, Mexico.
dc.contributor.emailazazel_vamp@yahoo.com.mx
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAV
dc.relation.journalPharmacology Biochemistry and Behavior
dc.identifier.placeEstados Unidos
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1873-5177
dc.identifier.doi10.1016/j.pbb.2021.173237
dc.subject.kwAntidepressant
dc.subject.kwCocaine
dc.subject.kwEnriched environment
dc.subject.kwLocomotor sensitization
dc.subject.kwMirtazapine
dc.subject.kwPharmacotherapies


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