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Cannabis use in people with obsessive-compulsive symptomatology: Results from a mexican epidemiological sample

dc.creatorNicolini, Humbertoes_ES
dc.creatorMartínez-Magaña, José Jaimees_ES
dc.creatorGenis-Mendoza, Alma Deliaes_ES
dc.creatorVillatoro Velázquez, Jorge Amethes_ES
dc.creatorCamarena, Beatrizes_ES
dc.creatorFleiz Bautista, Claraes_ES
dc.creatorBustos-Gamiño, Marycarmenes_ES
dc.creatorAguilar García, Alejandroes_ES
dc.creatorLanzagorta, Nuriaes_ES
dc.creatorMedina-Mora, María Elenaes_ES
dc.date2021
dc.date.accessioned2024-03-21T20:28:14Z
dc.date.available2024-03-21T20:28:14Z
dc.date.issued2021
dc.identifierJC56DIEP21es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7928
dc.identifier.urihttps://doi.org/10.3389/fpsyt.2021.664228
dc.descriptionRecent studies suggest that the endocannabinoid system could play an important role in the physiopathology of obsessive-compulsive disorder (OCD). There are reports of effective treatment with derivatives of tetrahydrocannabinol (THC). The study of the genetic factor associated with psychiatric disorders has made possible an exploration of its contribution to the pharmacological response. However, very little is known about the genetic factor or the prevalence of cannabis use in the Mexican population with OCD. The objective of this study is to compare the prevalence of use and dependence on cannabis in individuals with obsessive-compulsive symptomatology (OCS) with that of individuals with other psychiatric symptoms (psychosis, depression, and anxiety), and to explore the association between genetic risk and use. The study includes a total of 13,130 individuals evaluated in the second stage of the 2016 National Survey of Drug, Alcohol, and Tobacco Use (Encodat 2016), with genetic analysis (polygenic risk scoring) of a subsample of 3,521 individuals. Obsessive symptomatology had a prevalence of 7.2% and compulsive symptomatology a prevalence of 8.6%. The proportion of individuals with OCS who had ever used cannabis was 23.4%, and of those with cannabis dependency was 2.7%, the latter figure higher than that in individuals with other psychiatric symptoms (hypomania, 2.6%; anxiety, 2.8%; depression, 2.3%), except psychosis (5.9%). Individuals with OCS who reported using cannabis had an increased genetic risk for cannabis dependence but not for OCD. We thus cannot know how the increased genetic risk of cannabis dependence in people with OCD is influenced by their pharmacological response to derivatives of THC. The results, however, suggest paths for future studies.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.relation12:664228
dc.rightsAcceso Cerradoes_ES
dc.titleCannabis use in people with obsessive-compulsive symptomatology: Results from a mexican epidemiological samplees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationGenomics Laboratory of Psychiatric and Neurodegenerative Diseases, National Institute of Genomic Medicine, Mexico City, Mexico
dc.contributor.emailmetmmora@gmail.com (María Elena Medina-Mora) hnicolini@inmegen.gob.mx (Humberto Nicolini)
dc.relation.jnabreviadoFRONT PSYCHIATRY
dc.relation.journalFrontiers in Psychiatry
dc.identifier.placeSuiza
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1664-0640
dc.identifier.doi10.3389/fpsyt.2021.664228
dc.subject.kwObsessive-compulsive symptoms
dc.subject.kwCannabis use
dc.subject.kwMexican population
dc.subject.kwPolygenic risk score
dc.subject.kwCannabis dependence


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