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Impact of comorbid affective disorders on longitudinal clinical outcomes in individuals at ultra-high risk for psychosis

dc.creatorSchirmbeck, Frederikees_ES
dc.creatorBurg, Nadine C. van deres_ES
dc.creatorBlankers, Matthijses_ES
dc.creatorVermeulen, Jentien M.es_ES
dc.creatorMcGuire, Philipes_ES
dc.creatorValmaggia, Lucia R.es_ES
dc.creatorKempton, Matthew J.es_ES
dc.creatorGaag, Mark van deres_ES
dc.creatorRiecher-Rössler, Anitaes_ES
dc.creatorBressan, Rodrigo A.es_ES
dc.creatorBarrantes-Vidal, Neuses_ES
dc.creatorNelson, Barnabyes_ES
dc.creatorAmminger, G. Paules_ES
dc.creatorMcGorry, Patrickes_ES
dc.creatorPantelis, Christoses_ES
dc.creatorKrebs, Marie-Odile es_ES
dc.creatorRuhrmann, Stephanes_ES
dc.creatorSachs, Gabrielees_ES
dc.creatorRutten, Bart P. F.es_ES
dc.creatorOs, Jim vanes_ES
dc.creatorNordentoft, Meretees_ES
dc.creatorGlenthøj, Birtees_ES
dc.creatorEU-GEI High Risk Study Group Authorses_ES
dc.creatorFusar-Poli, Paoloes_ES
dc.creatorHaan, Lieuwe dees_ES
dc.creatorCalem, Mariaes_ES
dc.creatorTognin, Stefaniaes_ES
dc.creatorModinos, Gemmaes_ES
dc.creatorPisani, Saraes_ES
dc.creatorHedges, Emilyes_ES
dc.creatorVelthorst, Evaes_ES
dc.creatorKraan, Tamar C.es_ES
dc.creatorDam, Daniella S. vanes_ES
dc.creatorBurger, Nadinees_ES
dc.creatorPolitis, Athenaes_ES
dc.creatorGoodall, Joannees_ES
dc.creatorBorgwardt, Stefanes_ES
dc.creatorStuderus, Eriches_ES
dc.creatorGadelha, Aryes_ES
dc.creatorBrietzke, Elisaes_ES
dc.creatorAsevedo, Gracciellees_ES
dc.creatorAsevedo, Elsones_ES
dc.creatorZugman, Andrees_ES
dc.creatorDomínguez-Martínez, Tecellies_ES
dc.creatorMonsonet, Maneles_ES
dc.creatorHinojosa, Lidiaes_ES
dc.creatorRacioppi, Annaes_ES
dc.creatorKwapil, Thomas R.es_ES
dc.creatorKazes, Mathildees_ES
dc.creatorDaban, Clairees_ES
dc.creatorBourgin, Juliees_ES
dc.creatorGay, Olivieres_ES
dc.creatorMam-Lam-Fook, Céliaes_ES
dc.creatorNordholm, Dortees_ES
dc.creatorRanders, Lassees_ES
dc.creatorKrakauer, Kristinees_ES
dc.creatorGlenthøj, Louise Birkedales_ES
dc.creatorGebhard, Dominikaes_ES
dc.creatorArnhold, Juliaes_ES
dc.creatorKlosterkötter, Joachimes_ES
dc.creatorLasser, Irises_ES
dc.creatorWinklbaur, Bernadettees_ES
dc.creatorDelespaul, Philippe A.es_ES
dc.date2022
dc.date.accessioned2024-01-26T18:46:06Z
dc.date.available2024-01-26T18:46:06Z
dc.date.issued2022
dc.identifierJC25DIEP21es_ES
dc.identifier.issn0586-7614
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7892
dc.identifier.urihttps://doi.org/10.1093/schbul/sbab088
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8781381/
dc.descriptionIntroduction: Diagnoses of anxiety and/or depression are common in subjects at Ultra-High Risk for Psychosis (UHR) and associated with extensive functional impairment. Less is known about the impact of affective comorbidities on the prospective course of attenuated psychotic symptoms (APS). Method: Latent class mixed modelling identified APS trajectories in 331 UHR subjects assessed at baseline, 6, 12, and 24 months follow-up. The prognostic value of past, baseline, and one-year DSM-IV depressive or anxiety disorders on trajectories was investigated using logistic regression, controlling for confounders. Cox proportional hazard analyses investigated associations with transition risk. Results: 46.8% of participants fulfilled the criteria for a past depressive disorder, 33.2% at baseline, and 15.1% at one-year follow-up. Any past, baseline, or one-year anxiety disorder was diagnosed in 42.9%, 37.2%, and 27.0%, respectively. Participants were classified into one of three latent APS trajectory groups: (1) persistently low, (2) increasing, and (3) decreasing. Past depression was associated with a higher risk of belonging to the increasing trajectory group, compared to the persistently low (OR = 3.149, [95%CI: 1.298-7.642]) or decreasing group (OR = 3.137, [1.165-8.450]). In contrast, past (OR = .443, [.179-1.094]) or current (OR = .414, [.156-1.094]) anxiety disorders showed a trend-level association with a lower risk of belonging to the increasing group compared to the persistently low group. Past depression was significantly associated with a higher risk of transitioning to psychosis (HR = 2.123, [1.178-3.828]). Conclusion: A past depressive episode might be a particularly relevant risk factor for an unfavorable course of APS in UHR individuals. Early affective disturbances may be used to advance detection, prognostic, and clinical strategies.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relation48(1):100-110
dc.rightsAcceso Cerradoes_ES
dc.titleImpact of comorbid affective disorders on longitudinal clinical outcomes in individuals at ultra-high risk for psychosises_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartment of Psychiatry, Amsterdam University Medical Center, Meibergdreef, University of Amsterdam, Amsterdam, the Netherlands
dc.contributor.emailn.f.schirmbeck@amsterdamumc.nl
dc.relation.jnabreviadoSCHIZOPHR BULL
dc.relation.journalSchizophrenia Bulletin
dc.identifier.placeEstados Unidos
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1745-1701
dc.identifier.doi10.1093/schbul/sbab088
dc.subject.kwUltra-high risk
dc.subject.kwComorbid
dc.subject.kwAnxiety
dc.subject.kwDepression
dc.subject.kwPsychosis
dc.subject.kwSchizophrenia
dc.subject.kwPrediction


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