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Prefrontal cortical thickness and clinical characteristics of long-term treatment response to valproate in bipolar disorder

dc.creatorRodríguez-Ramírez, Alejandra Monserrates_ES
dc.creatorCedillo-Ríos, Valentees_ES
dc.creatorBecerra-Palars, Claudiaes_ES
dc.creatorMeza-Urzúa, Fatimaes_ES
dc.creatorJiménez-Pavón, Joannaes_ES
dc.creatorMorales-Cedillo, Pamelaes_ES
dc.creatorLópez-Titla, María Margaritaes_ES
dc.creatorSánchez-Segura, César Leonardoes_ES
dc.creatorMartínez-Gudiño, María de Lourdeses_ES
dc.creatorOrtega-Ortiz, Hirames_ES
dc.creatorCamarena-Medellin, Beatrizes_ES
dc.date2021
dc.date.accessioned2024-01-08T18:34:03Z
dc.date.available2024-01-08T18:34:03Z
dc.date.issued2021
dc.identifierOE08DSC21es_ES
dc.identifier.issn0925-4927
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7865
dc.identifier.urihttps://doi.org/10.1016/j.pscychresns.2021.111382
dc.descriptionValproate compositions are frequently used to treat bipolar disorder (BD); however, 87% of patients do not report full response in the long-term. There is scarce information about the clinical features and brain structural characteristics of long-term treatment response (LTTR) to this medication. In this study, we aim to evaluate the clinical characteristics and prefrontal cortical thickness (CT) of LTTR to valproate in BD. We evaluated 30 BD outpatients on valproate treatment, and 20 controls with a 3T T1-weighted 3D brain scan and Alda's scale for LTTR. An analysis of covariance was used to evaluate CT measures and a logistic regression was conducted to predict the full response (FR) using clinical features and CT measures. Patients with an insufficient response (IR) reported thinner right frontal eye fields, anterior and dorsolateral prefrontal cortexes compared with controls. FR patients presented thicker right dorsolateral prefrontal cortex than IR and no differences with controls. Patients with mixed features presented increased odds of achieving FR, while CT measures reported non-significant results. This is the first study to report mixed features as a clinical predictor of valproate LTTR. Our findings also suggest better preservation of the right prefrontal cortex of subjects with FR to valproate.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation317:111382
dc.rightsAcceso Cerradoes_ES
dc.titlePrefrontal cortical thickness and clinical characteristics of long-term treatment response to valproate in bipolar disorderes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacogenética, México.
dc.contributor.emailcamare@imp.edu.mx
dc.relation.jnabreviadoPSYCHIATRI RES NEUROIMAGING
dc.relation.journalPsychiatry Research. Neuroimaging
dc.identifier.placePaíses Bajos
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7506
dc.identifier.doi10.1016/j.pscychresns.2021.111382
dc.subject.kwMagnetic resonance imaging
dc.subject.kwMood disorders
dc.subject.kwMood stabilizers
dc.subject.kwNeuroimaging


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