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Neuropsychiatric genetics of psychosis in the mexican population: a genome-wide association study protocol for schizophrenia, schizoaffective, and bipolar disorder patients and controls

dc.creatorCamarena, Beatrizes_ES
dc.creatorAtkinson, Elizabeth G.es_ES
dc.creatorBaker, Markes_ES
dc.creatorBecerra-Palars, Claudiaes_ES
dc.creatorChibnik, Lori B.es_ES
dc.creatorEscamilla-Orozco, Raúles_ES
dc.creatorJiménez-Pavón, Joannaes_ES
dc.creatorKoenig, Zanes_ES
dc.creatorMárquez-Luna, Carlaes_ES
dc.creatorMartin, Alicia R.es_ES
dc.creatorMorales-Cedillo, Ingrid Pamelaes_ES
dc.creatorOlivares, Ana Mariaes_ES
dc.creatorOrtega-Ortiz, Hirames_ES
dc.creatorRodriguez-Ramíreza, Alejandra Monserrates_ES
dc.creatorSaracco-Alvarez, Ricardoes_ES
dc.creatorBasaldua, Rebecca E.es_ES
dc.creatorSena, Brena F.es_ES
dc.creatorKoenen, Karestan C.es_ES
dc.date2021
dc.date.accessioned2024-01-04T17:37:23Z
dc.date.available2024-01-04T17:37:23Z
dc.date.issued2021
dc.identifierOE05DSC21es_ES
dc.identifier.issn2673-3005
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7862
dc.identifier.urihttps://doi.org/10.1159/000518926
dc.descriptionNo large-scale genome-wide association studies (GWASs) of psychosis have been conducted in Mexico or Latin America to date. Schizophrenia and bipolar disorder in particular have been found to be highly heritable and genetically influenced. However, understanding of the biological basis of psychosis in Latin American populations is limited as previous genomic studies have almost exclusively relied on participants of Northern European ancestry. With the goal of expanding knowledge on the genomic basis of psychotic disorders within the Mexican population, the National Institute of Psychiatry Ramón de la Fuente Muñiz (INPRFM), the Harvard T.H. Chan School of Public Health, and the Broad Institute's Stanley Center for Psychiatric Research launched the Neuropsychiatric Genetics Research of Psychosis in Mexican Populations (NeuroMex) project to collect and analyze case-control psychosis samples from 5 states across Mexico. This article describes the planned sample collection and GWAS protocol for the NeuroMex study. The 4-year study will span from April 2018 to 2022 and aims to recruit 9,208 participants: 4,604 cases and 4,604 controls. Study sites across Mexico were selected to ensure collected samples capture the genomic diversity within the Mexican population. Blood samples and phenotypic data will be collected during the participant interview process and will contribute to the development of a local biobank in Mexico. DNA extraction will be done locally and genetic analysis will take place at the Broad Institute in Cambridge, MA. We will collect extensive phenotypic information using several clinical scales. All study materials including phenotypic instruments utilized are openly available in Spanish and English. The described study represents a long-term collaboration of a number of institutions from across Mexico and the Boston area, including clinical psychiatrists, clinical researchers, computational biologists, and managers at the 3 collaborating institutions. The development of relevant data management, quality assurance, and analysis plans are the primary considerations in this protocol article. Extensive management and analysis processes were developed for both the phenotypic and genetic data collected. Capacity building, partnerships, and training between and among the collaborating institutions are intrinsic components to this study and its long-term success.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherKargeres_ES
dc.relation7(3-4):60-70
dc.rightsAcceso Cerradoes_ES
dc.titleNeuropsychiatric genetics of psychosis in the mexican population: a genome-wide association study protocol for schizophrenia, schizoaffective, and bipolar disorder patients and controlses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationPharmacogenetics Department, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City, Mexico.
dc.contributor.affiliationcamare@imp.edu.mx
dc.relation.jnabreviadoCOMPLEX PSYCHIATRY
dc.relation.journalComplex Psychiatry
dc.identifier.placeSuiza
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2673-298X
dc.identifier.doi10.1159/000518926
dc.subject.kwBipolar disorder
dc.subject.kwGenome-wide association studies
dc.subject.kwMexico
dc.subject.kwNeuropsychiatric genetics
dc.subject.kwPsychosis
dc.subject.kwSchizophrenia


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