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Antitumor therapy under hypoxic microenvironment by the combination of 2-methoxyestradiol and sodium dichloroacetate on human non-small-cell lung cancer

dc.creatorRomero, Yaires_ES
dc.creatorCastillejos-López, Manueles_ES
dc.creatorRomero-García, Susanaes_ES
dc.creatorSalgado Aguayo, Alfonsoes_ES
dc.creatorHerrera, Ilianaes_ES
dc.creatorGarcia-Martin, Misael O.es_ES
dc.creatorTorres-Espíndola, Luz Mariaes_ES
dc.creatorNegrete-García, Maria Cristinaes_ES
dc.creatorCamarena Olvera, Angeles_ES
dc.creatorHuerta-Cruz, Juan Carloses_ES
dc.creatorVelázquez-Cruz, Rafaeles_ES
dc.creatorCisneros, Josées_ES
dc.creatorFlores Soto, Edgares_ES
dc.creatorSolís-Chagoyán, Héctores_ES
dc.creatorMendoza-Milla, Criseldaes_ES
dc.creatorCabello-Gutiérrez, Carloses_ES
dc.creatorRuiz, Víctores_ES
dc.creatorAquino-Gálvez, Arnoldoes_ES
dc.date2020
dc.date.accessioned2023-11-21T19:41:14Z
dc.date.available2023-11-21T19:41:14Z
dc.date.issued2020
dc.identifierJC06SIC20es_ES
dc.identifier.issn1942-0900
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7831
dc.identifier.urihttps://doi.org/10.1155/2020/3176375
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7603622/
dc.descriptionA hypoxic microenvironment is a hallmark in different types of tumors; this phenomenon participates in a metabolic alteration that confers resistance to treatments. Because of this, it was proposed that a combination of 2-methoxyestradiol (2-ME) and sodium dichloroacetate (DCA) could reduce this alteration, preventing proliferation through the reactivation of aerobic metabolism in lung adenocarcinoma cell line (A549). A549 cells were cultured in a hypoxic chamber at 1% O2 for 72 hours to determine the effect of this combination on growth, migration, and expression of hypoxia-inducible factors (HIFs) by immunofluorescence. The effect in the metabolism was evaluated by the determination of glucose/glutamine consumption and the lactate/glutamate production. The treatment of 2-ME (10 μM) in combination with DCA (40 mM) under hypoxic conditions showed an inhibitory effect on growth and migration. Notably, this reduction could be attributed to 2-ME, while DCA had a predominant effect on metabolic activity. Moreover, this combination decreases the signaling of HIF-3α and partially HIF-1α but not HIF-2α. The results of this study highlight the antitumor activity of the combination of 2-ME 10 μl/DCA 40 mM, even in hypoxic conditions.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherHindawi Pub. Corp.es_ES
dc.relation3176375
dc.rightsAcceso Cerradoes_ES
dc.titleAntitumor therapy under hypoxic microenvironment by the combination of 2-methoxyestradiol and sodium dichloroacetate on human non-small-cell lung canceres_ES
dc.typeArtículoes_ES
dc.contributor.affiliationFacultad de Ciencias, Universidad Nacional Autónoma de México, CDMX, Mexico.
dc.contributor.emailvicoruz@yahoo.com.mx (Víctor Ruiz) ; araquiga@yahoo.com.mx (Arnoldo Aquino-Gálvez)
dc.relation.jnabreviadoOXID MED CELL LONGEV
dc.relation.journalOxidative Medicine and Cellular Longevity
dc.identifier.placeEstados Unidos
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1942-0994
dc.identifier.doi10.1155/2020/3176375


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