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CACNA1C Risk Variant and Mood Stabilizers Effects in the Prefrontal Cortical Thickness of Mexican Patients with Bipolar Disorder

dc.creatorRodríguez-Ramírez, Alejandra Monserrates_ES
dc.creatorMeza-Urzúa, Fátimaes_ES
dc.creatorCedillo-Ríos, Valentees_ES
dc.creatorBecerra-Palars, Claudiaes_ES
dc.creatorJiménez-Pavón, Joannaes_ES
dc.creatorMorales-Cedillo, Ingrid Pamelaes_ES
dc.creatorSanabrais-Jiménez, Marco Antonioes_ES
dc.creatorHernández-Muñoz, Sandraes_ES
dc.creatorCamarena-Medellín, Beatrizes_ES
dc.date2020
dc.date.accessioned2023-10-18T18:14:52Z
dc.date.available2023-10-18T18:14:52Z
dc.date.issued2020
dc.identifierOE03DSC20es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7786
dc.identifier.urihttps://doi: 10.2147/NDT.S245911
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229798/
dc.descriptionPurpose: Bipolar disorder (BD) is a condition associated with structural alterations in the prefrontal cortex (PFC); some genetic variants and mood stabilizer medications like lithium or valproate are associated with these changes. CACNA1C is a gene involved in BD pathology and brain function; carriers of the A allele of rs1006737 are reported to have increased risk for BD and increased cortical thickness (CT) in the PFC compared to non-carriers. Lithium is also associated with increased CT in the PFC of BD subjects compared to the ones on valproate. The influence of these treatments and gene variants over the PFC structure of Mexican subjects has not been explored. Therefore, we evaluate the effects of mood stabilizers and risk A allele of CACNA1C rs1006737 on the prefrontal cortical thickness of Mexican BD patients treated with lithium or valproate. Patients and methods: A cross-sectional study of 40 BD type I euthymic adult outpatients (20 treated with lithium and 20 with valproate) who underwent a 3T T1-weighted 3D brain scan and genotyping for CACNA1C risk allele rs1006737 was conducted. We performed a cortical thickness analysis of the dorsolateral and orbitofrontal regions of the prefrontal cortex with BrainVoyager 20.6. The effects of treatment and gene variants were analyzed with a two-way multivariate analysis of covariance. Results: There was no association of CACNA1C risk allele rs1006737 with CT measures of both PFCs nor significant interaction between the genetic variant and treatment. Mood stabilizers reported the main effect on the CT measures of the right PFC of our sample. Patients on treatment with lithium showed higher mean CT on the right orbitofrontal cortex. Conclusion: We did not find any association between the prefrontal CT and CACNA1C risk A allele rs1006737 in BD Mexican patients treated with lithium or valproate. Our results suggest that mood stabilizers had the main effect in the CT of the right PFC.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherDove Medical Presses_ES
dc.relation12:16:1199-1206
dc.rightsAcceso Cerradoes_ES
dc.titleCACNA1C Risk Variant and Mood Stabilizers Effects in the Prefrontal Cortical Thickness of Mexican Patients with Bipolar Disorderes_ES
dc.typeArticuloes_ES
dc.contributor.affiliationDepartamento de Farmacogenética, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico.
dc.relation.jnabreviadoNeuropsychiatr Dis Treat
dc.relation.journalNeuropsychiatric Disease and Treatment.
dc.identifier.placeNueva Zelanda
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.doi10.2147/NDT.S245911
dc.subject.kwGenetics
dc.subject.kwMood Disorders
dc.subject.kwNeuroimaging


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