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dc.creatorFlores-Ramos, Mónicaes_ES
dc.creatorBecerra-Palars, Claudiaes_ES
dc.creatorHernández González, Consueloes_ES
dc.creatorChavira, Robertoes_ES
dc.creatorBernal-Santamaría, Normaes_ES
dc.creatorMartínez Mota, Lucíaes_ES
dc.date2020
dc.date.accessioned2023-10-18T15:36:01Z
dc.date.available2023-10-18T15:36:01Z
dc.date.issued2020
dc.identifierOE02DSC20es_ES
dc.identifier.issn1365-1501
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7781
dc.identifier.urihttps://doi.org/10.1080/13651501.2019.1680696
dc.descriptionObjective: to compare testosterone levels between female depressed patients and female bipolar patients.Methods: Sixty-one female patients with major depressive disorder (MDD) (n = 23) or bipolar disorder (BD) (n = 38) between 18 and 45 years old were included in the study. Participants were evaluated during a depressive or manic episode with the Hamilton depression rating scale (HDRS) or Young mania rating scale (YMRS), respectively. No patients in the MDD group were taken valproate while in the BD group 14 (36.84%) were taken valproate. Total testosterone (TT) and free testosterone (FT) levels were quantified during the early follicular phase of the cycle, with radioimmunoassay or solid phase enzyme-linked immunoassay. Data were collected from May 2016 to February 2017.Results: Mean TT serum levels were significantly higher in BD patients in comparison to MDD patients. Although age and diagnosis were related to TT levels, however when we added valproate use in the analysis, only the relation between TT and valproate use remained significant.Conclusions: In this sample, TT levels were related to valproate use in patients with BD. More studies regarding the role of testosterone in affective symptoms should be conducted to clarify the relation between testosterone, affective disorders, and medication.KeypointsWe observed that testosterone levels were significant higher in bipolar women compared to women with MDD.The use of valproate could be associated with the testosterone levels in female patients with BD.Evaluation of women suffering BD should include a testosterone levels determination, particularly when they are taking valproate.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherInforma Healthcarees_ES
dc.relation24(1):53-58
dc.rightsAcceso Cerradoes_ES
dc.titleSerum testosterone levels in bipolar and unipolar depressed female patients and the role of medication statuses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationConsejo Nacional de Ciencia y Tecnología (CONACyT), Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México City, México.
dc.contributor.emailflores_ramos@hotmail.com
dc.relation.jnabreviadoINT J PSYCHIATRY CLIN PRACT
dc.relation.journalInternational Journal of Psychiatry in Clinical Practice
dc.identifier.placeInglaterra
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1471-1788
dc.identifier.doi10.1080/13651501.2019.1680696
dc.subject.kwBipolar disorder
dc.subject.kwAndrogens
dc.subject.kwMajor depressive disorder
dc.subject.kwTestosterone
dc.subject.kwWomen


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