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Brain perfusion during manic episode and at 6-month followup period in bipolar disorder patients: correlation with cognitive functions

dc.creatorEstudillo-Guerra, Maria Anayalies_ES
dc.creatorPacheco-Barrios, Kevines_ES
dc.creatorCardenas-Rojas, Alejandraes_ES
dc.creatorAdame-Ocampo, Gloriaes_ES
dc.creatorCamprodon, Joan A.es_ES
dc.creatorMorales‐Quezada, Leones_ES
dc.creatorGutiérrez‐Mora, Dorises_ES
dc.creatorFlores‐Ramos, Mónicaes_ES
dc.date2020
dc.date.accessioned2023-09-20T17:53:39Z
dc.date.available2023-09-20T17:53:39Z
dc.date.issued2020
dc.identifierOE03DE20es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7766
dc.identifier.urihttps://doi.org/10.1002/brb3.1615
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303383/
dc.descriptionBackground: Patterns of altered cerebral perfusion and cognitive dysfunction have been described in Bipolar Disorder (BD) acute episodes and euthymia. Knowledge of the relationship between cognitive function and perfusion in a manic state and status when followed up is still limited. Objective: To describe brain perfusion alterations and its relationship with cognitive impairment in patients with BD during manic episodes and after 6 months. Methods: Observational-prospective study in 10 type I BD adults during moderate-severe manic episodes. We assessed sociodemographic data and clinical variables as well as cognitive function through Screening for Cognitive Impairment in Psychiatry (SCIP-S). Finally, we performed a Brain Perfusion SPECT using a Tc99m-ethyl cysteine dimer. Results: During manic episodes, patients showed cognitive impairment with a mean SCIP-S score of 63.8 ± 17.16. This was positively correlated with perfusion measured as relative reuptake index (RRI) at the right temporal pole (ρ = 0.65 p = .0435) and negatively correlated with right the orbitofrontal cortex (ρ = -0.70 p = .0077) and the right subgenual cingulate cortex (ρ = -0.70 p = .0256). Episode severity measured by the Young Mania Rating Scale (YMRS) positively correlated with RRI at the right temporal pole (ρ = 0.75, p = .01). At follow-up, six patients were taking treatment and were euthymic, we found a negative correlation with the YMRS and RRI at the bilateral orbitofrontal cortex (ρ = -0.8827, p = .019). They did not show significant improvement in cognitive performance at SCIP-S, and there was negative correlation with the following of the SCIP-S subscales; processing speed with the bilateral dorsolateral prefrontal, the bilateral medial prefrontal, the left temporal pole cortex RRI, and verbal fluency with the bilateral anterior cingulate cortex RRI. Conclusion: Cognitive impairment was correlated with brain perfusion patterns at baseline and follow-up. Large sample size studies with longer follow-up are needed to describe the changes in perfusion and cognitive functions in BD.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherJohn Wiley & Sonses_ES
dc.relation10(6):e01615
dc.rightsAcceso Cerradoes_ES
dc.titleBrain perfusion during manic episode and at 6-month followup period in bipolar disorder patients: correlation with cognitive functionses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationClínica de Trastornos de Afecto, National Institute of Psychiatry "Ramón de la Fuente Muñiz", México City, México.
dc.contributor.emailflores_ramos@hotmail.com (Monoica Flores Ramos)
dc.relation.jnabreviadoBRAIN BEHAV
dc.relation.journalBrain and behavior
dc.identifier.placeUnited States
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2162-3279
dc.identifier.doi10.1002/brb3.1615
dc.subject.kwBipolar disorder
dc.subject.kwEmission-Computed
dc.subject.kwFunctional neuroimaging
dc.subject.kwSingle-Photon
dc.subject.kwTomography


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