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Cortisol and DHEA-S levels in pregnant women with severe anxiety

dc.creatorLeff-Gelman, Philippees_ES
dc.creatorFlores Ramos, Mónicaes_ES
dc.creatorAvila Carrasco, Ariela Edithes_ES
dc.creatorLópez Martínez, Margaritaes_ES
dc.creatorSaravia Takashima, María Fernandaes_ES
dc.creatorCruz Coronel, Fausto Manueles_ES
dc.creatorFarfán Labonne, Blancaes_ES
dc.creatorZorrilla Dosal, José Antonioes_ES
dc.creatorChávez-Peón, Paola Barriguetees_ES
dc.creatorGarza Morales, Saules_ES
dc.creatorCamacho-Arroyo, Ignacioes_ES
dc.date2020
dc.date.accessioned2023-09-18T19:18:21Z
dc.date.available2023-09-18T19:18:21Z
dc.date.issued2020
dc.identifierOE02DE20es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7761
dc.identifier.urihttps://doi.org/10.1186/s12888-020-02788-6
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7409431/
dc.descriptionBackground: A complex interaction between cortisol and dehydroepiandrosterone-sulphate (DHEA-S) is crucial in the stress system balance; several studies have reported increased cortisol levels during chronic stress and a weak counterregulation by DHEA-S. During pregnancy, scarce information about this system is available, although cortisol and DHEA-S play an important role in the initiation and acceleration of labor. We conducted the present study in order to determine both cortisol and DHEA-S levels during the last trimester of pregnancy in patients exhibiting severe anxiety. Methods: Pregnant women during the 3rd trimester of pregnancy were evaluated by using the self-reported version of the Hamilton Anxiety Rating Scale (HARS). According to the scores obtained from the psychometric scale, participants were divided into two groups: 1) patients exhibiting a cutoff score > 15 were considered with severe anxiety (ANX) (n = 101), and control pregnant subjects (CTRL) (n = 44) with a cutoff score < 5. Morning cortisol, DHEA-S and Cortisol/DHEA-S index were measured in all participants. Comparisons between groups were performed; additionally, correlations between clinical variables, biochemical data and HARS were calculated. Results: Cortisol levels were significantly higher in the ANX group (p < 0.001), whereas those of DHEA-S were significantly lower in the same group (p < 0.01) when compared to healthy pregnant subjects. An increased cortisol/ DHEA-S index was observed in the ANX group (p < 0.05). A significant association between cortisol and HARS scores (p = 0.03), was observed even after adjusting by gestational weeks (p = 0.004). Conclusions: Our data support that the cortisol/DHEA-S index is higher in pregnant women with high anxiety levels as compared with healthy pregnant women.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.relation20(1):393
dc.rightsAcceso Cerradoes_ES
dc.titleCortisol and DHEA-S levels in pregnant women with severe anxietyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría, 14370, CDMX Mexico City, Mexico.
dc.contributor.emailpleff@ymail.com
dc.relation.jnabreviadoBMC PSYCHIATRY
dc.relation.journalBMC Psychiatry
dc.identifier.placeInglaterra
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1471-244X
dc.identifier.doi10.1186/s12888-020-02788-6
dc.subject.kwAnxiety
dc.subject.kwCortisol
dc.subject.kwCortisol/DHEA-S ratio
dc.subject.kwPregnancy
dc.subject.kwSerum levels
dc.subject.kwSteroids


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