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The cytokine profile of women with severe anxiety and depression during pregnancy

dc.creatorLeff Gelman, P.es_ES
dc.creatorMancilla-Herrera, I.es_ES
dc.creatorFlores-Ramos, M.es_ES
dc.creatorSaravia Takashima, M. F.es_ES
dc.creatorCruz Coronel, F. M.es_ES
dc.creatorCruz Fuentes, C.es_ES
dc.creatorPérez Molina, A.es_ES
dc.creatorHernández-Ruiz, J.es_ES
dc.creatorSilva-Aguiñlera, F. S.es_ES
dc.creatorFarfan-Labonne, B.es_ES
dc.creatorChinchilla-Ochoa, D.es_ES
dc.creatorGarza Morales, S.es_ES
dc.creatorCamacho-Arroyo, I.es_ES
dc.date2019
dc.date.accessioned2023-09-18T17:13:29Z
dc.date.available2023-09-18T17:13:29Z
dc.date.issued2019
dc.identifierOE01DE20es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7760
dc.identifier.urihttps://doi.org/10.1186/s12888-019-2087-6
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446269/
dc.descriptionBackground: Controversial findings regarding the association between pro-inflammatory cytokines and depression have been reported in pregnant subjects. Scarce data about anxiety and its relationships with cytokines are available in pregnant women. To understand the association between anxiety and cytokines during pregnancy, we conducted the present study in women with or without depression. Methods: Women exhibiting severe depression (SD) and severe anxiety (SA) during the 3rd trimester of pregnancy (n = 139) and control subjects exhibiting neither depression nor anxiety (n = 40) were assessed through the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS). Serum cytokines were measured by a multiplex bead-based assay. Correlation tests were used to analyze the data and comparisons between groups were performed. A general linear model of analysis of variance was constructed using the group as a dependent variable, interleukin concentrations as independent variables, and HDRS/HARS scores and gestational weeks as covariables. Results: The highest levels of Th1- (IL-6, TNF-α, IL-2, IFN-γ), Th17- (IL-17A, IL-22), and Th2- (IL-9, IL-10, and IL-13) related cytokines were observed in women with SD + SA. The SA group showed higher concentrations of Th1- (IL-6, TNF-α, IL2, IFN-γ) and Th2- (IL-4, and IL-10) related cytokines than the controls. Positive correlations were found between HDRS and IL-2, IL-6, and TNF-α in the SA group (p < 0.03), and between HDRS and Th1- (IL-2, IL-6, TNF-α), Th2- (IL-9, IL-10, IL13) and Th17- (IL-17A) cytokines (p < 0.05) in the SD + SA group. After controlling the correlation analysis by gestational weeks, the correlations that remained significant were: HDRS and IL-2, IL-6, IL-9, and IL-17A in the SD + SA group (p < 0.03). HARS scores correlated with IL-17A in the SA group and with IL-17A, IL-17F, and IL-2 in the SD + SA group (p < 0.02). The linear model of analysis of variance showed that HDRS and HARS scores influenced cytokine concentrations; only IL-6 and TNF-α could be explained by the group. Conclusions: We found that the cytokine profiles differ when comparing pregnant subjects exhibiting SA with comorbid SD against those showing only SA without depression.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.relation19(1):104
dc.rightsAcceso Cerradoes_ES
dc.titleThe cytokine profile of women with severe anxiety and depression during pregnancyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationInstituto Nacional de Pernatologia, Isidro Espinosa de los Reyes, Montes Urales # 800, Col Lomas de Virreyes, 11000, (Mexico City), CD MX, Mexico.
dc.contributor.emailpleff@ymail.com
dc.relation.jnabreviadoBMC PSYCHIATRY
dc.relation.journalBMC Psychiatry
dc.identifier.placeInglaterra
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1471-244X
dc.identifier.doi10.1186/s12888-019-2087-6
dc.subject.kwCytokines
dc.subject.kwInflammation
dc.subject.kwPregnancy
dc.subject.kwDepression
dc.subject.kwAnxiety


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