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Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk

dc.creatorCristóbal-Narváez, Paulaes_ES
dc.creatorSheinbaum, Tamaraes_ES
dc.creatorRosa, Aracelies_ES
dc.creatorCastro-Catala, Marta dees_ES
dc.creatorDomínguez-Martínez, Tecellies_ES
dc.creatorKwapil, Thomas R.es_ES
dc.creatorBarrantes-Vidal, Neuses_ES
dc.date2020
dc.date.accessioned2023-09-01T18:49:52Z
dc.date.available2023-09-01T18:49:52Z
dc.date.issued2020
dc.identifierJC24DIEP20es_ES
dc.identifier.issn0924-9338
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7749
dc.identifier.urihttps://doi.org/10.1192/j.eurpsy.2019.4
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315877/
dc.descriptionBackground: There is limited research on the interaction of both positive and negative daily-life environments with stress-related genetic variants on psychotic experiences (PEs) and negative affect (NA) across the extended psychosis phenotype. This study examined whether the FK506 binding protein 51 (FKBP5) variability moderates the association of positive and negative experiences in the moment with PEs and NA in participants with incipient psychosis and their nonclinical counterparts. Methods: A total of 233 nonclinical and 86 incipient psychosis participants were prompted for a 1-week period to assess their day-to-day experiences. Participants were genotyped for four FKBP5 single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080). Results: Multilevel analyses indicated that, unlike the risk haplotype, the protective FKBP5 haplotype moderated all the associations of positive experiences with diminished PEs and NA in incipient psychosis compared with nonclinical group. Conclusions: Participants with incipient psychosis showed symptomatic improvement when reporting positive appraisals in the interpersonal domain, which suggests that these act as a powerful coping mechanism. The fact that this occurred in daily-life underscores the clinical significance of this finding and pinpoints the importance of identifying protective mechanisms. In addition, results seem to concur with the vantage sensitivity model of gene-environment interaction, which poses that certain genetic variants may enhance the likelihood of benefiting from positive exposures.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherCambridge University Presses_ES
dc.relation63(1):e11
dc.rightsAcceso Cerradoes_ES
dc.titleInteraction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis riskes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationParc Sanitari Sant Joan de Déu, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
dc.contributor.emailneus.barrantes@uab.cat (Neus Barrantes-Vidal)
dc.relation.jnabreviadoEUR PSYCHIATRY
dc.relation.journalEuropean Psychiatry
dc.identifier.placeInglaterra
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1778-3585
dc.identifier.doi10.1192/j.eurpsy.2019.4
dc.subject.kwGene–environment interaction
dc.subject.kwEcological validity
dc.subject.kwExperience sampling methodology
dc.subject.kwIncipient psychosis
dc.subject.kwVantage sensitivity


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