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Effect of dialyzable leukocyte extract, sodium butyrate, and valproic acid in the development of anergy in murine leprosy

dc.creatorRojas-Espinosa, Oscares_ES
dc.creatorMoreno-García, Sandraes_ES
dc.creatorArce-Paredes, Patriciaes_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorJuárez-Ortega, Marioes_ES
dc.date2020
dc.date.accessioned2023-08-14T17:23:36Z
dc.date.available2023-08-14T17:23:36Z
dc.date.issued2020
dc.identifierJC36NC20es_ES
dc.identifier.issn2212-5531
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7724
dc.identifier.urihttp://doi.org/10.4103/ijmy.ijmy_31_20
dc.descriptionBackground: Murine leprosy is a chronic granulomatous disease caused by Mycobacterium lepraemurium (MLM) in mice and rats. The disease evolves with the development of cellular anergy that impedes the production of interferon gamma (IFNγ), tumor necrosis factor-alpha (TNFα), and nitric oxide (NO) required to kill the microorganism. In this study we investigated whether histone deacetylase inhibitors (HDACi) (valproic acid and sodium butyrate [NaB]) and the immunomodulator transfer factor in dialyzable leukocyte extracts (DLE) can prevent anergy in murine leprosy. Methods: Five groups of six Balb/c mice were intraperitoneally inoculated with 2 × 107 MLM. Thirty-days post inoculation, treatment was started; one group received no treatment, one was treated with rifampicin-clofazimine (R-C), one with sodium valproate (VPA), one with NaB, and one with DLE. The animals were monitored for the evidence of disease for 96 days. After euthanasia, their spleens were removed and processed for histologic, bacteriologic, and cytokine studies. Results: R-C completely controlled the ongoing disease. DLE and NaB significantly reduced the development of lesions, including granuloma size and the number of bacilli; VPA was less effective. DLE, NaB, and VPA reverted the anergic condition in diverse grades and allowed the expression of IFNγ, TNFα, and inducible NO synthase, also in diverse grades. Conclusion: Anergy in leprosy and murine leprosy allows disease progression. In this study, anergy was prevented, in significant degree, by DLE (an immunomodulator) and NaB (HDACi). VPA was less effective. These results suggest potential beneficial effects of DLE and NaB in the ancillary treatment of leprosy.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation9(3):268-273
dc.rightsAcceso Cerradoes_ES
dc.titleEffect of dialyzable leukocyte extract, sodium butyrate, and valproic acid in the development of anergy in murine leprosyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartment of Immunology, National School of Biological Sciences, National Polytechnic Institute
dc.contributor.emailrojas_espinosa@hotmail.com (Rojas‑Espinosa, Oscar)
dc.relation.jnabreviadoINT J MYCOBACTERIOL
dc.relation.journalInternational Journal of Mycobacteriology
dc.identifier.placeIndia
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2212-554X
dc.identifier.doi10.4103/ijmy.ijmy_31_20
dc.subject.kwAnergy
dc.subject.kwDialyzable leukocytes extract
dc.subject.kwMurine leprosy
dc.subject.kwSodium butyrate
dc.subject.kwValproic acid


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