Mostrar el registro sencillo del ítem

Antinociceptive and anxiolytic-like effects of a neo-clerodane diterpene from Salvia semiatrata aerial parts

dc.creatorOrtiz-Mendoza, Nancyes_ES
dc.creatorZavala-Ocampo, Lizeth M.es_ES
dc.creatorMartínez-Gordillo, Martha J.es_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorBasurto Peña, Francisco A.es_ES
dc.creatorBazany-Rodríguez, Iván J.es_ES
dc.creatorRivera Chávez, José Albertoes_ES
dc.creatorDorazco-González, Alejandroes_ES
dc.creatorAguirre-Hernández, Evaes_ES
dc.date2020
dc.date.accessioned2023-07-26T19:32:34Z
dc.date.available2023-07-26T19:32:34Z
dc.date.issued2020
dc.identifierJC29NC20
dc.identifier.issn1388-0209
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7717
dc.identifier.urihttps://doi.org/10.1080/13880209.2020.1784235
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7471977/
dc.descriptionContext: Salvia semiatrata Zucc. (Lamiaceae) is a species used as a tranquilizer and to relieve pain in folk medicine in Santiago Huauclilla, Oaxaca, Mexico. Objective: To evaluate the antinociceptive and anxiolytic-like effects of S. semiatrata extracts and identify a bioactive metabolite. Materials and methods: The extracts were obtained by maceration of S. semiatrata aerial parts using solvents in increasing polarity (hexane, ethyl acetate and methanol). A neo-clerodane diterpene was extracted from the ethyl acetate fraction using open column chromatography. Identification of this metabolite was performed by crystallography, 1H NMR, 13C NMR, ATR-IR, ECD, MS and elemental analysis. The antinociceptive activity was explored using the writhing and formalin tests. Whereas, the anxiolytic-like responses were analysed in the open-field, hole-board and plus-maze tests. All the treatments were administered using oral gavage in male CD1 mice and explored 30 min after administration of the individual extracts (300 mg/kg) or the compound 1 (0.1, 1 or 10 mg/kg). Results: All the extracts produced significant reduction in the nociceptive and anxiety-like behaviour compared to mice treated with the vehicle (0.5% tween 80 in saline solution). The spectroscopic analysis corroborated the presence of the neo-clerodane diterpene 7-keto-neoclerodan-3,13-dien-18,19:15,16-diolide (1), as partial responsible of the antinociceptive and anxiolytic-like effects, which produced a dose-dependent response in the writhing test with an ED50=4.15 mg/kg. Discussion and conclusions: These results reinforce the medicinal properties of S. semiatrata in folk medicine, where participation of a neo-clerodane diterpene was evidenced in the inhibitory central nervous system activity of this species.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francises_ES
dc.relation58(1) 620-629
dc.rightsAcceso Cerradoes_ES
dc.titleAntinociceptive and anxiolytic-like effects of a neo-clerodane diterpene from Salvia semiatrata aerial partses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Productos Naturales, Departamento de Ecología y Recursos Naturales, Facultad de Ciencias, Universidad Nacional Autónoma de México, CDMX, México
dc.contributor.emaileva_aguirre@ciencias.unam.mx (Eva Aguirre-Hernández)
dc.relation.jnabreviadoPHARM BIOL
dc.relation.journalPharmaceutical Biology
dc.identifier.placeInglaterra
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1744-5116
dc.identifier.doi10.1080/13880209.2020.1784235
dc.subject.kwAnxiety
dc.subject.kwLamiaceae
dc.subject.kwNeoclerodanes terpenoids
dc.subject.kwNociception
dc.subject.kwSalvias
dc.subject.kwTraditional medicine


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem