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Melatonin effects on EEG activity during non-rapid eye movement sleep in mild-to-moderate Alzheimer´s disease: a pilot study

dc.creatorCruz-Aguilar, Manuel Alejandroes_ES
dc.creatorRamírez-Salado, Ignacioes_ES
dc.creatorHernández-González, Mariselaes_ES
dc.creatorGuevara, Miguel Angeles_ES
dc.creatorMolina del Río, Jahazieles_ES
dc.date2021
dc.date.accessioned2023-06-22T16:47:26Z
dc.date.available2023-06-22T16:47:26Z
dc.date.issued2021
dc.identifierJC26NC20es_ES
dc.identifier.issn0020-7454
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7714
dc.identifier.urihttps://doi.org/10.1080/00207454.2020.1750392
dc.descriptionIntroduction: There is evidence to suggest that melatonin diminishes non-rapid eye movement sleep (NREMS) latency in patients with Alzheimer´s disease (AD). However, melatonin's effects on cortical activity during NREMS in AD have not been studied. The objective of this research was to analyze the effects of melatonin on cortical activity during the stages of NREMS in 8 mild-to-moderate AD patients that received 5-mg of fast-release melatonin. Methods: During a single-blind, placebo-controlled crossover study, polysomnographic recordings were obtained from C3-A1, C4-A2, F7-T3, F8-T4, F3-F4 and O1-O2. Also, the relative power (RP) and EEG coherences of the delta, theta, alpha1, alpha2, beta1, beta2 and gamma bands were calculated during NREMS-1, NREMS-2 and NREMS-3. These sleep latencies and all EEG data were then compared between the placebo and melatonin conditions. Results: During NREMS-2, a significant RP increase was observed in the theta band of the left-central hemisphere. During NREMS-3, significant RP decreases in the beta bands were recorded in the right-central hemisphere, compared to the placebo group. After melatonin administration, significant decreases of EEG coherences in the beta2, beta1 and gamma bands were observed in the right hemisphere during NREMS-3. Discussion: We conclude that short NREMS onset related to melatonin intake in AD patients is associated with a significant RP increase in the theta band and a decrease in RP and EEG coherences in the beta and gamma bands during NREMS-3. These results suggest that the GABAergic pathways are preserved in mild-to-moderate AD.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherInforma Healthcarees_ES
dc.relation131(6):580-590
dc.rightsAcceso Cerradoes_ES
dc.titleMelatonin effects on EEG activity during non-rapid eye movement sleep in mild-to-moderate Alzheimer´s disease: a pilot studyes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz," Dirección de Investigaciones en Neurociencias, Laboratorio de Cronobiología y Sueño, CDMX, México.
dc.contributor.emailmacrag@gmail.com (Manuel Alejandro Cruz-Aguilar)
dc.relation.jnabreviadoINT J NEUROSCI
dc.relation.journalInternational Journal of Neuroscience
dc.identifier.placeInglaterra
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1563-5279
dc.identifier.doi10.1080/00207454.2020.1750392
dc.subject.kwPolysomnography
dc.subject.kwAlzheimer´s disease
dc.subject.kwEEG coherence
dc.subject.kwBeta EEG band
dc.subject.kwMelatonin
dc.subject.kwNon-rapid eye movement sleep


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