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Study of antispasmodic and antidiarrheal activities of tagetes lucida (Mexican Tarragon) in experimental models and its mechanism of action

dc.creatorVentura-Martinez, Rosaes_ES
dc.creatorAngeles-Lopez, Guadalupe Estheres_ES
dc.creatorGonzalez-Trujano, Maria Evaes_ES
dc.creatorCarrasco, Omar F.es_ES
dc.creatorDeciga-Campos, Myrnaes_ES
dc.date2020
dc.date.accessioned2023-06-14T16:31:56Z
dc.date.available2023-06-14T16:31:56Z
dc.date.issued2020
dc.identifierJC25NC20es_ES
dc.identifier.issn1741-427X
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7713
dc.identifier.urihttps://doi.org/10.1155/2020/7140642
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7641699/
dc.descriptionTagetes lucida has been used in traditional medicine as a remedy to alleviate several gastrointestinal disorders that provoke stomachaches, abdominal cramps, and diarrhea. However, there is not enough scientific evidence that supports these effects. Therefore, the purpose of this study was to evaluate antispasmodic and antidiarrheal activities of aqueous extract of T. lucida (AqExt-TL) as well as its mechanism of action in experimental models. Antispasmodic activity and the mechanism of action of AqExt-TL were assessed on segments of the guinea pig ileum precontracted with KCl, acetylcholine (ACh), or electrical field stimulation (EFS). Furthermore, the antispasmodic effect of two coumarins (umbelliferone and herniarin) previously identified in this species was evaluated. Antidiarrheal activity of AqExt-TL was determined using the charcoal meal test in mice. AqExt-TL showed antispasmodic activity in segments of the guinea pig ileum precontracted with KCl (83.7 ± 1.9%) and ACh (77.2 ± 5.3%) at the maximal concentration; however, practically, it did not alter the contractions induced by EFS (10.1 ± 2.2%). Antispasmodic activity of AqExt-TL was not significantly altered by hexamethonium (a ganglionic blocker) or L-NAME (an inhibitor of nitric oxide synthase). However, this extract decreased the maximal contractile response to calcium (82.7 ± 8.5%), serotonin (68.1 ± 8.5%), and histamine (63.9 ± 5.9%) in their concentration-response curves. Umbelliferone and herniarin also induced an antispasmodic effect on tissues precontracted with KCl. In addition, low doses of AqExt-TL reduced to 50% the distance traveled by charcoal meal in the gastrointestinal transit model in mice as loperamide, an antidiarrheal agent, did. These results provided evidence of the antispasmodic and antidiarrheal activity of T. lucida, which supports its use in the folk medicine in relieving symptoms in some gastrointestinal disorders. In the antispasmodic effect, the blockade of histaminergic and serotoninergic pathway as well as the calcium channels seems to be involved. Finally, umbelliferone and herniarin could be partially responsible for the antispasmodic activity induced by T. lucida.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherHindawi Pub.es_ES
dc.relation7140642
dc.rightsAcceso Cerradoes_ES
dc.titleStudy of antispasmodic and antidiarrheal activities of tagetes lucida (Mexican Tarragon) in experimental models and its mechanism of actiones_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad No. 3000, Col. Copilco Universidad, Ciudad Universitaria, 04510 Ciudad de México, Mexico
dc.contributor.emailrventuram7@hotmail.com (Rosa Ventura-Martinez)
dc.relation.jnabreviadoEVID BASED COMPLEMENT ALTERNAT MED
dc.relation.journalEvidence-Based Complementary and Alternative Medicine
dc.identifier.placeEstados Unidos
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1741-4288
dc.identifier.doi10.1155/2020/7140642


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