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Dehydroepiandrosterone increases tonic and phasic dopamine release in the striatum

dc.creatorPérez-Neri, Ivánes_ES
dc.creatorParra, Dorises_ES
dc.creatorAquino-Miranda, Guillermoes_ES
dc.creatorCoffeen, Uliseses_ES
dc.creatorRíos, Camiloes_ES
dc.date2020
dc.date.accessioned2023-06-09T17:16:50Z
dc.date.available2023-06-09T17:16:50Z
dc.date.issued2020
dc.identifierJC20NC20es_ES
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7708
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2020.135095
dc.descriptionDehydroepiandrosterone (DHEA) modulates dopaminergic neurotransmission. It takes part in neurologic and psychiatric diseases involving monoamine neurotransmitters. Earlier results show that DHEA (120-min treatment) reduced striatal dopamine (DA) turnover in rats, suggesting a reduced DA release. Some investigations report that DHEA increases DA release but inhibits motor activity, which seems contradictory. This research examines the effect of DHEA on striatal DA release, its metabolism and motor activity. Male Wistar rats were implanted in the striatum with a cannula for in vivo microdialysis. DHEA was administered (120 mg/kg) and dialysates were collected for 280 min. A depolarizing stimulus was applied at 120 min. Samples were analyzed by HPLC-ED to determine the concentration of DA and its metabolites. The effect of DHEA on motor activity was also evaluated during 120 min. Extracellular DA concentration was greater in treated animals both before and after depolarization. In contrast, DHEA reduced the areas below the curves for DA metabolites and DA/metabolite ratios. DHEA also reduced motor activity, remarkably in the first 20 min after treatment. In summary, DHEA yielded a stimulatory effect on striatal DA release that was not reflected in neither DA metabolism nor motor activity. Thus, DHEA resembles the effect of typical antipsychotics, increasing DA release but reducing behavioral activation.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherNEUROSCI LETTes_ES
dc.relation734:135095
dc.rightsAcceso Cerradoes_ES
dc.titleDehydroepiandrosterone increases tonic and phasic dopamine release in the striatumes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartment of Neurochemistry, National Institute of Neurology and Neurosurgery, Insurgentes sur 3877, La Fama, Tlalpan, 14269 Mexico City, Mexico
dc.contributor.emailivanperezneri@hotmail.com (I. Pérez-Neri), borita88@hotmail.com (D. Parra), gumo57900@hotmail.com (G. Aquino-Miranda), coffen@imp.edu.mx (U. Coffeen), crios@correo.xoc.uam.mx (C. Ríos).
dc.relation.jnabreviadoNeuroscience Letters
dc.identifier.placeIrlanda
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramon de la Fuente Muñiz
dc.identifier.eissn1872-7972
dc.identifier.doi10.1016/j.neulet.2020.135095
dc.subject.kwAntipsychotic
dc.subject.kwDehydroepiandrosterone
dc.subject.kwDopamine transporter
dc.subject.kwMicrodialysis
dc.subject.kwNeuroprotection
dc.subject.kwSchizophrenia


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