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Sexually dimorphic dynamics of thyroid axis activity during fasting in rats

dc.creatorJoseph-Bravo, Patriciaes_ES
dc.creatorLazcano, Ivánes_ES
dc.creatorJaimes-Hoy, Lorrainees_ES
dc.creatorGutierrez-Mariscal, Marianaes_ES
dc.creatorSanches-Jaramillo, Edithes_ES
dc.creatorUribe, Rosa Maríaes_ES
dc.creatorCharli, Jean-Louises_ES
dc.date2020
dc.date.accessioned2023-06-06T18:45:39Z
dc.date.available2023-06-06T18:45:39Z
dc.date.issued2020
dc.identifierJC18NC20es_ES
dc.identifier.issn2768-6701
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7706
dc.identifier.urihttps://doi.org/10.2741/4857
dc.descriptionStarvation induces tertiary hypothyroidism in adult rodents. Response of the hypothalamus-pituitary-thyroid (HPT) axis to starvation is stronger in adult males than in females. To improve the description of this sexual dimorphism, we analyzed the dynamics of HPT axis response to fasting at multiple levels. In adult rats of the same cohort, 24 and 48 h of starvation inhibited paraventricular nucleus Trh expression and serum concentrations of TSH and T4 earlier in males than in females, with lower intensity in females than in males. In adult females fasted for 36-72 h, serum TSH concentration decreased after 36 h, when the activity of thyrotropin-releasing hormone (TRH)-degrading ectoenzyme was increased in the median eminence. The kinetics of these events were distinct from those previously observed in male rats. We suggest that the sex difference in TSH secretion kinetics is driven not only at the level of paraventricular nucleus TRH neurons, but also by differences in post-secretory catabolism of TRH, with enhancement of TRH-degrading activity more sustained in male than female animals.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherIMR Presses_ES
dc.relation25(7):1305-1323
dc.rightsAcceso Cerradoes_ES
dc.titleSexually dimorphic dynamics of thyroid axis activity during fasting in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartment of Developmental Genetics and Molecular Physiology, Institute of Biotechnology, National University of Mexico (UNAM), Cuernavaca, Mexico.
dc.contributor.emailcharli@ibt.unam.mx (Jean-Louis Charli)
dc.relation.jnabreviadoFRONT BIOSCI (Landmark Ed)
dc.relation.journalFrontiers in Bioscience (Landmark edition)
dc.identifier.placeSingapur
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2768-6698
dc.identifier.doi10.2741/4857


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