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Quality attributes of partially hydrolyzed collagen in a liquid formulation used for skin care

dc.creatorMejía-Calvo, Ignacioes_ES
dc.creatorLópez-Juárez, Leonardo E.es_ES
dc.creatorVázquez-Leyva, Saides_ES
dc.creatorLópez-Morales, Carlos A.es_ES
dc.creatorMontoya-Escutia, Danieles_ES
dc.creatorMerlos Rivera, Pamela G.es_ES
dc.creatorHerbert-Pucheta, José Enriquees_ES
dc.creatorZepeda-Vallejo, Luis Gerardoes_ES
dc.creatorVelasco-Velázquez, Marcoes_ES
dc.creatorPavón, Lenines_ES
dc.creatorPérez-Tapia, Sonia M.es_ES
dc.creatorMedina-Rivero, Emilioes_ES
dc.date2020
dc.date.accessioned2023-06-05T15:48:06Z
dc.date.available2023-06-05T15:48:06Z
dc.date.issued2020
dc.identifierJC17NC2020es_ES
dc.identifier.issn1473-2130
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7705
dc.identifier.urihttps://doi.org/10.1111/jocd.13439
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818267/
dc.descriptionBackground: The deterioration of the skin accentuates over time, affecting its aesthetic appearance. This is characterized by the weakening of the mechanisms involved in the regeneration and repair of the dermal matrix. Consequently, the skin losses elasticity and smoothness resulting in the formation of wrinkles. The alternatives for facial rejuvenation include surgery, injection of botulinum toxin, and the application of masks. Topic products are less invasive, can be self-applied, and have an increased benefit/risk relationship. Aim: We developed a liquid formulation containing collagen hydrolyzed and evaluated the product by cutting-edge technology in order to define proper its quality attributes. Methods: We employed nuclear magnetic resonance (NMR), size-exclusion chromatography (SEC), and mass spectrometry (MS). Additionally, we analyzed its cosmetical effect in five volunteers and we demonstrate the product safety. Results: Our results demonstrate the following: (a) a stable secondary structure identity associated to the known triple helix arrangement in liquid and solid states; (b) a typical conformational flexibility depending on its hydration state; (c) thermal stability confirmed by liquid- and solid-state nuclear magnetic resonance schemes; and (d) a molecular mass distribution of peptides between 0.5 and 19.5 kDa. The product faded wrinkles in the forehead, an effect that remained after removing the mask. The formula was non-irritating and hypoallergenic. Conclusion: We characterized, using state-of-the-art methodologies, the quality attributes that are critical for the safety and beneficial effect of a new collagen-containing formula.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBlackwell Science,es_ES
dc.relation20(1):150-158
dc.rightsAcceso Cerradoes_ES
dc.titleQuality attributes of partially hydrolyzed collagen in a liquid formulation used for skin carees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico
dc.contributor.emailsperezt@ipn.mx (Sonia Mayra Pérez-Tapia) emilio.medina@udibi.com.mx (Emilio Medina-Rivero)
dc.relation.jnabreviadoJ COSMET DERMATOL
dc.relation.journalJournal of Cosmetic Dermatology
dc.identifier.placeInglaterra
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1473-2165
dc.identifier.doi10.1111/jocd.13439
dc.subject.kwHydrolyzed collagen
dc.subject.kwLiquid formulation
dc.subject.kwQuality attributes cosmetic
dc.subject.kwAafety cosmetic product
dc.subject.kwSkin aging


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