Mostrar el registro sencillo del ítem

Melatonin Modulates Dendrite Maturation and Complexity in the Dorsal- and Ventral- Dentate Gyrus Concomitantly with Its Antidepressant-Like Effect in Male Balb/C Mice

dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.creatorPalacios-Cabriales, Diana Montserrates_ES
dc.creatorOrtiz-López, Leonardoes_ES
dc.creatorEstrada-Camarena, Erika Montserrates_ES
dc.creatorVega-Rivera, Nelly Maritzaes_ES
dc.date2020
dc.date.accessioned2023-05-30T15:55:11Z
dc.date.available2023-05-30T15:55:11Z
dc.date.issued2020
dc.identifierJC14NC20es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7702
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084558/
dc.identifier.urihttps://doi.org/10.3390/ijms21051724
dc.descriptionAdult neurogenesis occurs in the dentate gyrus (DG) of the hippocampus. New neurons help to counteract the effects of stress and several interventions including antidepressant drugs, environmental modifications and internal factors act pro-neurogenic with consequences in the dorsal and ventral DG. Melatonin, the main product synthesized by the pineal gland, induces antidepressant-like effects and modulates several events of the neurogenic process. However, the information related to the capability of melatonin to modulate dendrite maturation and complexity in the dorsal and ventral regions of the DG and their correlation with its antidepressant-like effect is absent. Thus, in this study, we analyzed the impact of melatonin (0, 0.5, 1, 2.5, 5 or 10 mg/kg) administered daily for fourteen days on the number, dendrite complexity and distribution of doublecortin (DCX)-cells in the dorsal-ventral regions of the DG in male Balb/C mice. Doublecortin is a microtubule-associated protein that is expressed during the course of dendritic maturation of newborn neurons. Also, we analyzed the impact of melatonin on despair-like behavior in the forced swim test. We first found a significant increase in the number and higher dendrite complexity, mainly with the doses of 2.5, 5 and 10 mg/kg of melatonin (81%, 122%, 78%). These cells showed more complex dendritic trees in the ventral- and the dorsal- DG. Concomitantly, the doses of 5 and 10 mg/kg of melatonin decreased depressant-like behavior (76%, 82%). Finally, the data corroborate the antidepressant-like effect of melatonin and the increasing number of doublecortin-associated cells. Besides, the data indicate that melatonin favors the number and dendrite complexity of DCX-cells in the dorsal- and ventral- region of the DG, which may explain part of the antidepressant-like effect of melatonin.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation21(5):1724
dc.rightsAcceso Cerradoes_ES
dc.titleMelatonin Modulates Dendrite Maturation and Complexity in the Dorsal- and Ventral- Dentate Gyrus Concomitantly with Its Antidepressant-Like Effect in Male Balb/C Micees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratory of Neurogenesis, Division of Clinical Investigations, National Institute of Psychiatry “Ramón de la Fuente Muñiz”, Calzada México-Xochimilco No. 101, Mexico City C.P. 14370, Mexico
dc.contributor.emailgbernabe@imp.edu.mx (G.B.R.-R.); nmvega@imp.edu.mx (N.M.V.-R.)
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.identifier.placeSuiza
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1422-0067
dc.identifier.doi10.3390/ijms21051724
dc.subject.kwAdult neurogenesis
dc.subject.kwMelatonin
dc.subject.kwDorsal-ventral hippocampus
dc.subject.kwDoublecortin
dc.subject.kwForced-swim
dc.subject.kwDepression


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem