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Antihypertensive and vasorelaxant mode of action of the ethanol-soluble extract from Tagetes lucida Cav. aerial parts and its main bioactive metabolites

dc.creatorEstrada-Soto, Samueles_ES
dc.creatorGonzález-Trujano, Ma. Evaes_ES
dc.creatorRendón-Vallejo, Priscilaes_ES
dc.creatorArias-Durán, Luises_ES
dc.creatorÁvila-Villarreal, Gabrielaes_ES
dc.creatorVillalobos-Molina, Rafaeles_ES
dc.date2021
dc.date.accessioned2023-05-26T17:53:48Z
dc.date.available2023-05-26T17:53:48Z
dc.date.issued2021
dc.identifierJC10NC20es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7698
dc.identifier.urihttps://doi.org/10.1016/j.jep.2020.113399
dc.descriptionEthnopharmacological relevance: Tagetes lucida Cav. commonly known as "yauhtli" or "pericón" is used in Mexican traditional medicine for the treatment of anxiety, depressant diseases, pain, hypertension, among others. Aim: To evaluate the antihypertensive and vasorelaxant modes of action of a crude ethanolic extract from T. lucida aerial parts and to isolate the bioactive compounds. Materials and methods: Ethanolic extract was tested in an in vivo assay in SHR rats by intragastric administration at 10 and 100 mg/kg dosages, to measure and to compare hemodynamic parameters like diastolic and systolic blood pressure and heart rate. Also, extract (3.03-1000 μg/ml), fractions (3.03-1000 μg/ml) and pure isolated compounds (1.75-550 μM) were evaluated on isolated aortic rings contracted with noradrenaline (0.1 μM) to determine their vasorelaxant effect and extract-mode of action. Results: Ethanolic extract of T. lucida lowered systolic and diastolic blood pressure on SHR rats without heart rate modification (P > 0.05). Moreover, the extract showed concentration-dependent relaxant effect in a partially endothelium-dependent manner (P < 0.05), through NO/cGMP system activation and calcium channel blockade. 6,7,8-trimethoxycoumarin (1), 6,7-dimethoxycoumarin (2), and 7-methoxycoumarin (3) from T. lucida are the main bioactive compounds of the extract and showed significant vasorelaxant activity. Conclusions: Results provide evidence and endorsed the antihypertensive properties attributed to T. lucida in traditional medicine, which is produced by vasorelaxant effect mainly through multitarget NO/cGMP system activation and calcium channel blockade. Coumarin derivatives 1, 2 and 3 are the responsible of the vasorelaxant activity.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevier Sequoiaes_ES
dc.relation266:113399
dc.rightsAcceso Cerradoes_ES
dc.titleAntihypertensive and vasorelaxant mode of action of the ethanol-soluble extract from Tagetes lucida Cav. aerial parts and its main bioactive metaboliteses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
dc.contributor.emailenoch@uaem.mx (S. Estrada-Soto), evagontru@yahoo.com.mx (Ma. E. González-Trujano)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.identifier.placeIrlanda
dc.date.published2021
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2020.113399
dc.subject.kwAntihypertensive
dc.subject.kwCalcium channel blockade
dc.subject.kwCoumarins
dc.subject.kwNO/cGMP system
dc.subject.kwTagetes lucida
dc.subject.kwVasorelaxant


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