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Role of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oil

dc.creatorHernandez-Leon, Albertoes_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorNarváez-González, Fernandoes_ES
dc.creatorPérez-Ortega, Gimenaes_ES
dc.creatorRivero-Cruz, Faustoes_ES
dc.creatorAguilar, María Isabeles_ES
dc.date2020
dc.date.accessioned2023-05-23T17:38:39Z
dc.date.available2023-05-23T17:38:39Z
dc.date.issued2020
dc.identifierJC04NC20es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7691
dc.identifier.urihttps://doi.org/10.3390/molecules25030675
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037113/
dc.descriptionTagetes lucida Cav. (Asteraceae) is an ancient medicinal plant commonly used to alleviate pain. Nevertheless, scientific studies validating this property are lacking in the literature. Animal models of pain were used to evaluate the antinociceptive and anti-inflammatory activities of T. lucida essential oil (TLEO) and a bioactive metabolite. The chemical constitution and possible toxicity of the extract and the mechanism of action of β-caryophyllene were also explored. Temporal course curves and dose-response graphics were generated using TLEO (0.1-10 mg/kg or 3.16-31.62 mg/kg) and β-caryophyllene (3.16-10 mg/kg). Metamizole (80 mg/kg) and indomethacin (20 mg/kg) were used as reference drugs in the formalin assay and writhing test in rats and mice, respectively. The β-caryophyllene mechanism of action was explored in the presence of naloxone (1 mg/kg), flumazenil (10 mg/kg), WAY100635 (0.16 mg/kg), or nitro-l-arginine methyl ester (L-NAME) (20 mg/kg) in the formalin test in rats. GC/MS analysis demonstrated the presence of geranyl acetate (49.89%), geraniol (7.92%), and β-caryophyllene (6.27%). Significant and dose-dependent antinociceptive response was produced by TLEO and β-caryophyllene without the presence of gastric damage. In conclusion, β-caryophyllene was confirmed as a bioactive compound in the T. lucida analgesic properties by involving the participation of receptors like opioids, benzodiazepines, and Serotonin 1A receptor (5-HT1A), as well as nitric oxide.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation25(3):675
dc.rightsAcceso Cerradoes_ES
dc.titleRole of β-Caryophyllene in the Antinociceptive and Anti-Inflammatory Effects of Tagetes lucida Cav. Essential Oiles_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México 14370, Mexico.
dc.contributor.emailevag@imp.edu.mx
dc.relation.jnabreviadoMOLECULES
dc.relation.journalMolecules
dc.identifier.placeSuiza
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1420-3049
dc.subject.kwAsteraceae
dc.subject.kwTagetes lucida Cav.
dc.subject.kwAnalgesic
dc.subject.kwEssential oil
dc.subject.kwTraditional medicine
dc.subject.kwβ-caryophyllene


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