Mostrar el registro sencillo del ítem

Perinatal exposure to octabromodiphenyl ether mixture, DE-79, alters the vasopressinergic system in adult rats

dc.creatorAlvarez-Gonzalez, Mhar Y.es_ES
dc.creatorSánchez-Islas, Eduardoes_ES
dc.creatorMucio-Ramirez, Samueles_ES
dc.creatorGortari, Patria dees_ES
dc.creatorAmaya, María I.es_ES
dc.creatorKodavanti, Prasa Rao S.es_ES
dc.creatorLeón-Olea, Marthaes_ES
dc.date2020
dc.date.accessioned2023-05-19T18:58:11Z
dc.date.available2023-05-19T18:58:11Z
dc.date.issued2020
dc.identifierJC03NC20es_ES
dc.identifier.issn0041-008X
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7690
dc.identifier.urihttps://doi.org/10.1016/j.taap.2020.114914
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8103815/
dc.descriptionPolybrominated diphenyl ethers (PBDEs) are persistent environmental pollutants considered as neurotoxicants and endocrine disruptors with important biological effects ranging from alterations in growth, reproduction, and effects on the hypothalamus-pituitary-adrenal axis. The vasopressinergic (AVPergic) system is a known target for pentaBDEs mixture (DE-71) and the structurally similar chemicals, polychlorinated biphenyls. However, the potential adverse effects of mixtures containing octaBDE compounds, like DE-79, on the AVPergic system are still unknown. The present study aims to examine the effects of perinatal DE-79 exposure on the AVPergic system. Dams were dosed from gestational day 6 to postnatal day 21 at doses of 0 (control), 1.7 (low) or 10.2 (high) mg/kg/day, and male offspring from all doses at 3-months-old were subjected to normosmotic and hyperosmotic challenge. Male offspring where later assessed for alterations in osmoregulation (i.e. serum osmolality and systemic vasopressin release), and both vasopressin immunoreactivity (AVP-IR) and gene expression in the hypothalamic paraventricular and supraoptic nuclei. Additionally, to elucidate a possible mechanism for the effects of DE-79 on the AVPergic system, both neuronal nitric oxide synthase immunoreactivity (nNOS-IR) and mRNA expression were investigated in the same hypothalamic nuclei. The results showed that perinatal DE-79 exposure AVP-IR, mRNA expression and systemic release in adulthood under normosmotic conditions and more evidently under hyperosmotic stimulation. nNOS-IR and mRNA expression were also affected in the same nuclei. Since NO is an AVP regulator, we propose that disturbances in NO could be a mechanism underlying the AVPergic system disruption following perinatal DE-79 exposure leading to osmoregulation deficits.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherAcademic Presses_ES
dc.relation391:114914
dc.rightsAcceso Cerradoes_ES
dc.titlePerinatal exposure to octabromodiphenyl ether mixture, DE-79, alters the vasopressinergic system in adult ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Neuromorfología Funcional, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México Xochimilco No. 101, Col. San Lorenzo Huipulco, Ciudad de México, C.P. 14370, Mexico
dc.contributor.emailmarthalo@imp.edu.mx
dc.relation.jnabreviadoTOXICOL APPL PHARMACOL
dc.relation.journalToxicology and Applied Pharmacology
dc.identifier.placeEstados Unidos
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1096-0333
dc.identifier.doi10.1016/j.taap.2020.114914
dc.subject.kwDE-79
dc.subject.kwNeuroendocrine disruptors
dc.subject.kwNitric oxide
dc.subject.kwOsmoregulation
dc.subject.kwPBDEs
dc.subject.kwVasopressin.


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem