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Age-dependent effects of testosterone on spatial memory in male rats

dc.creatorJiménez-Rubio, Gracielaes_ES
dc.creatorHerrera-Pérez, José Jaimees_ES
dc.creatorMartínez-Becerril, Hilda Angélicaes_ES
dc.creatorMárquez-Baltazar, Martín Sergioes_ES
dc.creatorMartínez-Mota, Lucíaes_ES
dc.date2020
dc.date.accessioned2023-05-19T17:29:44Z
dc.date.available2023-05-19T17:29:44Z
dc.date.issued2020
dc.identifierJC01NC20
dc.identifier.issn0018-506X
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7688
dc.identifier.urihttps://doi.org/10.1016/j.yhbeh.2020.104748
dc.descriptionDecreased spatial memory is common in aging populations and reduces their quality of life. Although its role is still controversial, low testosterone (T) may contribute to impaired cognition in aged men. This study aimed to identify the role of T in age-related deficiencies in spatial memory among male rats. Young adult (3 months old) and aged (21 months old) Wistar rats were assigned to independent groups: intact, orchidectomized, or orchidectomized + subcutaneous pellets of T propionate. The phases of spatial memory acquisition (4 daily trials/4 days) and spatial memory retention (1 trial/day, 3 and 12 days after acquisition) were evaluated using the Barnes maze. Compared with young adults, aged intact rats took longer to find the goal, made more mistakes, and showed only slight improvements in goal sector exploration across the acquisition period. The young orchidectomized rats showed no improvement in performance over the days during the acquisition phase. T treatment in hormonally deprived old rats produced a small improvement in goal sector exploration and number of errors during the acquisition phase. Meanwhile, in young adults, this treatment improved the goal sector searching in the retention phase (12 days after acquisition training). Our results suggested that age-related spatial memory deficits cannot be entirely explained by the decline in T levels; however, this androgen produced subtle and mild beneficial effects on spatial memory in young and old males. Taken together, our findings suggest age differences in the role of T on spatial memory in males.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherAcademic Presses_ES
dc.relation122:104748
dc.rightsAcceso Cerradoes_ES
dc.titleAge-dependent effects of testosterone on spatial memory in male ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Delegación Tlalpan, 14370 Ciudad de México, Mexico.
dc.contributor.emaillucia@imp.edu.mx (L. Martínez-Mota)
dc.relation.jnabreviadoHORM BEHAV
dc.relation.journalHormones and Behavior
dc.identifier.placeEstados Unidos
dc.date.published2020
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1095-6867
dc.identifier.doi10.1016/j.yhbeh.2020.104748
dc.subject.kwAging
dc.subject.kwBarnes maze
dc.subject.kwMemory
dc.subject.kwOrchidectomy
dc.subject.kwTestosterone


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