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Gastrointestinal activity of Justicia spicigera Schltdl. in experimental models

dc.creatorÁngeles-López, Guadalupe E.es_ES
dc.creatorGonzález-Trujano, Ma Evaes_ES
dc.creatorRodríguez, R.es_ES
dc.creatorDéciga-Campos, M.es_ES
dc.creatorBrindis, F.es_ES
dc.creatorVentura-Martínez, R.es_ES
dc.date2019
dc.date.accessioned2022-12-15T17:55:43Z
dc.date.available2022-12-15T17:55:43Z
dc.date.issued2019
dc.identifierJC31NC22es_ES
dc.identifier.issn1478-6419
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7656
dc.identifier.urihttps://doi.org/10.1080/14786419.2019.1637873
dc.descriptionJusticia spicigera Schltdl. (Acanthaceae) is used for treatment of gastrointestinal illnesses therapy in traditional medicine. The objective of this study was to give evidence of the antinociceptive and spasmolytic effects of the J. spicigera ethanol extract (JS EtOH) using in in vivo and/or in vitro assays. The JS EtOH exerted regulatory effect on the motility and a partial relaxing response on the intestinal tissue. Furthermore, a significant abdominal antinociceptive response was obtained in mice, which was totally abolished in the presence of 5-HT1A receptor antagonist (WAY100635, 0.1 mg/kg, s.c.) and partially by blocking opioid receptors (NX, 1 mg/kg, i.p.), whereas the inhibition of the NO synthesis (L-NAME, 30 mg/kg, i.p.) facilitated antinociception of this extract. Kaempferitrin was isolated and identified as major secondary metabolite. These results support the analgesic and spasmolytic-like activity of J. spicigera aerial parts involving inhibitory neurotransmission reinforcing the potential of this medicinal plant for alleviating pain.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francis Health Scienceses_ES
dc.relation35(11)1847-1851
dc.rightsAcceso Cerradoes_ES
dc.titleGastrointestinal activity of Justicia spicigera Schltdl. in experimental modelses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, Ciudad de México, México
dc.contributor.emailgeangeles@yahoo.com.mx (Guadalupe E. Ángeles-López)
dc.relation.jnabreviadoNAT PROD RES
dc.relation.journalNatural Product Research
dc.identifier.placeInglaterra
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1478-6427
dc.identifier.doi10.1080/14786419.2019.1637873
dc.subject.kwAntinociception
dc.subject.kwJusticia spicigera
dc.subject.kwintestinal motility
dc.subject.kwMedicinal plants
dc.subject.kwSpasmolytic effect


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