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Effects of high- and low-frequency stimulation of the thalamic reticular nucleus on pentylentetrazole-induced seizures in rats

dc.creatorMagdaleno-Madrigal, Víctor Manueles_ES
dc.creatorContreras-Murillo, Gerardoes_ES
dc.creatorValdés-Cruz, Alejandroes_ES
dc.creatorMartínez-Vargas, Davides_ES
dc.creatorMartínez, Adriánes_ES
dc.creatorVillasana-Salazar, Benjamínes_ES
dc.creatorAlmazán-Alvarado, Salvadores_ES
dc.date2019
dc.date.accessioned2022-12-07T18:08:12Z
dc.date.available2022-12-07T18:08:12Z
dc.date.issued2019
dc.identifierJC22NC22es_ES
dc.identifier.issn1094-7159
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7645
dc.identifier.urihttps://doi.org/10.1111/ner.12926
dc.descriptionRationale: The use of electrical stimulation therapy to treat epilepsy is currently being studied in experimental animals and patients. Our study was designed to evaluate the effects of electrical stimulation applied in the thalamic reticular nucleus (TRN) on the development of pentylentetrazole-induced seizures. Materials and methods: Experiments were performed using male Wistar rats with electrodes stereotaxically implanted in the left TRN. Epidural EEG recording screws were implanted in the motor cortex for EEG recording. The rats were classified in seven groups: one sham group, four groups receiving either high- or low-frequency preemptive stimulation for either 10 or 60 minutes, and two groups receiving either high- or low-frequency responsive stimulation for ten minutes. All animals received a single dose of pentylentetrazole throughout five days. EEG recordings were obtained from the cortex and were evaluated to assess ictal behavior more than 45 to 90 minutes. Results: Ten minutes of preemptive high-frequency stimulation in the TRN induced a significant decrease in seizure severity compared to 60 minutes of preemptive stimulation and ten minutes of responsive stimulation. Additionally, ten minutes of preemptive high-frequency stimulation protected against death as aftereffect of status epilepticus. The spike-wave complex frequency was not modified. Conclusions: These data could contribute to the characterization of the TRN in mediating the initiation and spreading of seizure activity and provide preclinical support for optimal parameters to use to obtain beneficial effects against convulsive activity.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation22(4) 425-434
dc.rightsAcceso Cerradoes_ES
dc.titleEffects of high- and low-frequency stimulation of the thalamic reticular nucleus on pentylentetrazole-induced seizures in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofisiología del Control y la Regulación. Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
dc.contributor.emailmaleno@imp.edu.mx (Manuel Magdaleno-Madrigal)
dc.relation.jnabreviadoNEUROMODULATION
dc.relation.journalNeuromodulation
dc.identifier.placeEstados Unidos
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1525-1403
dc.identifier.doi10.1111/ner.12926
dc.subject.kwDeep brain stimulation
dc.subject.kwHigh-frequency stimulation
dc.subject.kwLow-frequency stimulation
dc.subject.kwRat
dc.subject.kwThalamic reticular nucleus


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