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Increased expression of brain-derived neurotrophic factor transcripts I and VI, cAMP response element binding, and glucocorticoid receptor in the cortex of patients with temporal lobe epilepsy
| dc.creator | Martínez-Levy, G. A. | es_ES |
| dc.creator | Rocha, L. | es_ES |
| dc.creator | Rodríguez-Pineda, F. | es_ES |
| dc.creator | Alonso-Vanegas, M. A. | es_ES |
| dc.creator | Nani, A. | es_ES |
| dc.creator | Buentello-García, R. M. | es_ES |
| dc.creator | Briones-Velasco, M. | es_ES |
| dc.creator | San-Juan, D. | es_ES |
| dc.creator | Cienfuegos, J. | es_ES |
| dc.creator | Cruz-Fuentes, C. S. | es_ES |
| dc.date | 2018 | |
| dc.date.accessioned | 2022-11-29T16:59:52Z | |
| dc.date.available | 2022-11-29T16:59:52Z | |
| dc.date.issued | 2018 | |
| dc.identifier | MT07IC22 | |
| dc.identifier.issn | 0893-7648 | |
| dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/7641 | |
| dc.identifier.uri | https://doi.org/10.1007/s12035-017-0597-0 | |
| dc.description | A body of evidence supports a relevant role of brain-derived neurotrophic factor (BDNF) in temporal lobe epilepsy (TLE). Magnetic resonance data reveal that the cere bral atrophy extends to regions that are functionally and ana tomically connected with the hippocampus, especially the temporal cortex. We previously reported an increased expres sion of BDNF messenger for the exon VI in the hippocampus of temporal lobe epilepsy patients compared to an autopsy control group. Altered levels of this particular transcript were also associated with pre-surgical use of certain psychotropic. We extended here our analysis of transcripts I, II, IV, and VI to the temporal cortex since this cerebral region holds intrinsic communication with the hippocampus and is structurally af fected in patients with TLE. We also assayed the cyclic aden osine monophosphate response element-binding (CREB) and glucocorticoid receptor (GR) genes as there is experimental evidence of changes in their expression associated with BDNF and epilepsy. TLE and pre-surgical pharmacological treatment were considered as the primary clinical independent variables. | |
| dc.format | ||
| dc.language.iso | eng | |
| dc.publisher | Humana Press | |
| dc.relation | 55(5)3698-3708 | |
| dc.rights | Acceso Cerrado | |
| dc.title | Increased expression of brain-derived neurotrophic factor transcripts I and VI, cAMP response element binding, and glucocorticoid receptor in the cortex of patients with temporal lobe epilepsy | es_ES |
| dc.type | Artículo | |
| dc.contributor.affiliation | Department of Genetics, National Institute of Psychiatry Ramón de la Fuente Muñiz (INPRFM), Mexico City, Mexico | |
| dc.contributor.email | cruz@imp.edu.mx (Cruz-Fuentes, C.S.) | |
| dc.relation.jnabreviado | MOL NEUROBIOL | |
| dc.relation.journal | Molecular Neurobiology | |
| dc.identifier.place | Estados Unidos | |
| dc.date.published | 2018 | |
| dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | |
| dc.identifier.eissn | 1559-1182 | |
| dc.identifier.doi | 10.1007/s12035-017-0597-0 | |
| dc.subject.kw | Pharmacoresistant epilepsy | |
| dc.subject.kw | Temporal cortex | |
| dc.subject.kw | BDNF | |
| dc.subject.kw | CREB |
