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Accumbal TRH is downstream of the effects of isolation stress on hedonic food intake in rats

dc.creatorAlvarez-Salas, Elenaes_ES
dc.creatorGonzález, Aldoes_ES
dc.creatorAmaya, Maria Isabeles_ES
dc.creatorGortari, Patricia dees_ES
dc.date2019
dc.date.accessioned2022-11-28T19:24:23Z
dc.date.available2022-11-28T19:24:23Z
dc.date.issued2019
dc.identifierJC19NC22es_ES
dc.identifier.issn1028-415X
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7637
dc.identifier.urihttps://doi.org/10.1080/1028415X.2019.1657658
dc.descriptionEmotional stress, through elevating corticosterone (CORT) levels may reduce feeding in rodents however when offered palatable food, stressed animals ingest more food compared to non-stressed controls. Nucleus accumbens (NAc) is part of the mesocorticolimbic system and participates in processing rewarding characteristics of food modulating palatable food intake, mainly when glucocorticoids are elevated. A possible mediator of CORT effects is accumbal thyrotropin-releasing hormone (TRH), which reduces chow intake in rats when administered into the NAc. We aimed to study the TRH role in hedonic feeding in stressed rats. For 14 days, animals with ad libitum access to chow or chow plus chocolate milk were either group-housed or singly-housed to induce stress. Rats with access to chocolate milk showed hyperphagia and decreased accumbal TRH mRNA levels, which were potentiated by stress. Results suggest that TRH downregulation was permissive of the increased palatable food intake. TRH injections into NAc of singly-housed animals with palatable food access reduced their food intake and increased serum CORT levels. The accumbal injections of a glucocorticoid receptor antagonist (mifepristone) in stressed rats with palatable food access, reduced only palatable food intake and increased accumbal TRH expression and serum CORT levels. This modulation of TRH mRNA when CORT signaling is modified suggests that accumbal TRH is downstream of glucocorticoids activity, which specifically increase palatable food intake. Our results strengthen the TRH involvement in regulating emotional aspects of hedonic feeding in stressed animals. Finding new therapies directed towards increasing TRHergic activity in NAc may be protective against overeating.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francises_ES
dc.relation24(7)554-563
dc.rightsAcceso Cerradoes_ES
dc.titleAccumbal TRH is downstream of the effects of isolation stress on hedonic food intake in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationMolecular Neurophysiology Laboratory, Neurosciences Research Department, National Institute of Psychiatry Ramón de la Fuente, México City, México
dc.contributor.emailgortari@imp.edu.mx (Patricia de Gortari)
dc.relation.jnabreviadoNUTR NEUROSCI
dc.relation.journalNutritional Neuroscience
dc.identifier.placeInglaterra
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1476-8305
dc.identifier.doi10.1080/1028415X.2019.1657658
dc.subject.kwPalatable food
dc.subject.kwStress
dc.subject.kwThyrotropin-releasing hormone
dc.subject.kwNucleus accumbens
dc.subject.kwMifepristone


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