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Transcranial focal electrical stimulation via concentric ring electrodes in freely moving cats: antiepileptogenic and postictal effects

dc.creatorValdés-Cruz, Alejandroes_ES
dc.creatorVillasana-Salazar, Benjamínes_ES
dc.creatorWilliams, Brandones_ES
dc.creatorMartínez-Vargas, Davides_ES
dc.creatorMagdaleno-Madrigal, Víctor Manueles_ES
dc.creatorAlmazán-Alvarado, Salvadores_ES
dc.creatorBesio, Walter G.es_ES
dc.date2019
dc.date.accessioned2022-11-23T18:26:29Z
dc.date.available2022-11-23T18:26:29Z
dc.date.issued2019
dc.identifierJC16NC22es_ES
dc.identifier.issn0014-4886
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7631
dc.identifier.urihttps://doi.org/10.1016/j.expneurol.2019.113012
dc.descriptionTranscranial focal electrical stimulation (TFS) via tripolar concentric ring electrodes (TCRE), tripolar TFS, is proposed to treat pharmacoresistant epilepsy. We determined the effect of tripolar TFS on electrical amygdaloid kindling (AK) in freely moving cats. Fifteen cats were bilaterally implanted with electrodes in the amygdala (AM) and prefrontal cortex and assigned to three groups: the control group, which only received AK; the tripolar TFS before AK group, in which TCREs were placed over the vertex and tripolar TFS (300 Hz, 200 μs biphasic equal charge, square pulses) was delivered for 40 min just prior to AK; and the tripolar TFS after AK group, in which the TCREs were placed over the temporal bone ipsilateral to the kindled AM, while tripolar TFS was administered for 2 min just after AK onset for 40 days, and, thereafter, only AK was applied. AK was applied daily until all animals reached kindling stage VI. A three concentric spheres finite element cat head model was developed to analyze the electric fields caused by tripolar TFS. Tripolar TFS after AK inhibited kindling development. Animals with tripolar TFS after AK remained at the focal seizure stages for 20 days after tripolar TFS cessation and required 80.0 ± 15.42 AK stimulations to reach stage VI, significantly higher than TFS before AK, and control (P < .001). Tripolar TFS before AK did not show signs of protection against epileptogenesis. The finite modeling of tripolar TFS showed that the electric field is >0.3 mV/mm at depths less than approximately 12.6 mm in the cat brain, which should be strong enough to alter brain activity. In conclusion, tripolar TFS applied via a TCRE over the ipsilateral temporal area significantly delayed AK. This taken together with other reports of tripolar TFS aborting seizures in acute seizure models suggests that tripolar TFS is a promising new modality that should be considered for further testing.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherAcademic Presses_ES
dc.relation320:113012
dc.rightsAcceso Cerradoes_ES
dc.titleTranscranial focal electrical stimulation via concentric ring electrodes in freely moving cats: antiepileptogenic and postictal effectses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofisiología del Control y la Regulación, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco. Tlalpan, México City Zip Code 14370, Mexico
dc.contributor.emailalevalc@imp.edu.mx (A. Valdés-Cruz), bwilliams3@my.uri.edu (B. Williams), davmv@imp.edu.mx (D. Martínez-Vargas), maleno@imp.edu.mx (V.M. Magdaleno-Madrigal), salmazan@imp.edu.mx (S. Almazán-Alvarado), besio@uri.edu (W.G. Besio)
dc.relation.jnabreviadoEXP NEUROL
dc.relation.journalExperimental Neurology
dc.identifier.placeEstados Unidos
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1090-2430
dc.identifier.doi10.1016/j.expneurol.2019.113012
dc.subject.kwTranscranial focal electrical stimulation
dc.subject.kwTripolar concentric ring electrodes
dc.subject.kwElectrical amygdaloid kindling
dc.subject.kwEpileptogenesis
dc.subject.kwKindling development inhibition


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