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On the existence of mechanoreceptors within the neurovascular unit of the mammalian brain

dc.creatorLarriva-Sahd, Jorgees_ES
dc.creatorLeón-Olea, Marthaes_ES
dc.creatorVargas-Barroso, Víctores_ES
dc.creatorVarela-Echavarría, Alfredoes_ES
dc.creatorConcha, Luises_ES
dc.date2019
dc.date.accessioned2022-11-23T16:48:18Z
dc.date.available2022-11-23T16:48:18Z
dc.date.issued2019
dc.identifierJC15NC22es_ES
dc.identifier.issn1863-2653
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7630
dc.identifier.urihttps://doi.org/10.1007/s00429-019-01863-3
dc.descriptionWe describe a set of perivascular interneurons (PINs) with series of fibro-vesicular complexes (FVCs) throughout the gray matter of the adult rabbit and rat brains. PIN-FVCs are ubiquitous throughout the brain vasculature as detected in Golgi-impregnated specimens. Most PINs are small, aspiny cells with short or long (> 1 mm) axons that split and travel along arterial blood vessels. Upon ramification, axons form FVCs around the arising vascular branches; then, paired axons run parallel to the vessel wall until another ramification ensues, and a new FVC is formed. Cytologically, FVCs consist of clusters of perivascular bulbs (PVBs) encircling the precapillary and capillary wall surrounded by end-feet and the extracellular matrix of endothelial cells and pericytes. A PVB contains mitochondria, multivesicular bodies, and granules with a membranous core, similar to Meissner corpuscles and other mechanoreceptors. Some PVBs form asymmetrical, axo-spinous synapses with presumptive adjacent neurons. PINs appear to correspond to the type 1 nNOS-positive neurons whose FVCs co-label with markers of sensory fiber-terminals surrounded by astrocytic end-feet. The PIN is conserved in adult cats and rhesus monkey specimens. The location, ubiquity throughout the vasculature of the mammalian brain, and cytological organization of the PIN-FVCs suggests that it is a sensory receptor intrinsic to the mammalian neurovascular unit that corresponds to an afferent limb of the sensorimotor feed-back mechanism controlling local blood flow.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherSpringer-Verlages_ES
dc.relation224(6)2247-2267
dc.rightsAcceso Cerradoes_ES
dc.titleOn the existence of mechanoreceptors within the neurovascular unit of the mammalian braines_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartmento de Neuroiologia del Desarrollo y Fisiología, Instituto de Neurobiología. Campus Juriquilla, Universidad Nacional Autónoma de México, Boulevard Universitario 3001, 76230 Juriquilla, Querétaro, Mexico
dc.contributor.emailjlsneuro@unam.mx (Jorge Larriva-Sahd)
dc.relation.jnabreviadoBRAIN STRUCT FUNCT
dc.relation.journalBrain Structure & Function
dc.identifier.placeAlemania
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1863-2661
dc.identifier.doi10.1007/s00429-019-01863-3
dc.subject.kwReceptor
dc.subject.kwBlood vessels
dc.subject.kwPerivascular organ
dc.subject.kwEnd-foot
dc.subject.kwCentral blood fow


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