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Anxiolytic- and anxiogenic-like effects of Montanoa tomentosa (Asteraceae): Dependence on the endocrine condition

dc.creatorEstrada-Camarena, Erikaes_ES
dc.creatorSollozo-Dupont, Isabeles_ES
dc.creatorIslas-Preciado, Danniaes_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorCarro-Juárez, Migueles_ES
dc.creatorLópez-Rubalcava, Carolinaes_ES
dc.date2019
dc.date.accessioned2022-11-22T19:16:44Z
dc.date.available2022-11-22T19:16:44Z
dc.date.issued2019
dc.identifierJC14NC22es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7628
dc.identifier.urihttps://doi.org/10.1016/j.jep.2019.112006
dc.descriptionEthnopharmacological relevance: Montanoa tomentosa Cerv. (MT) is a native plant from Mexico used in traditional medicine as a remedy for reproductive impairments and relaxing effects. In previous studies, it has been shown that the endocrine state could modify the antianxiety-like actions of anxiolytic compounds. Although women are the primary user of MT, no studies have evaluated the potential impact of the endocrine milieu on its anti-anxiety actions. Aims of the study: Ascertain the antianxiety effects of M. tomentosa in rats with different hormonal conditions, and to analyze the participation of the GABAA receptor in ovariectomized rats treated with MT. Materials and methods: The animal model of anxiety used was the elevated plus-maze (EPM). Rats' endocrine conditions were: a) Low hormone levels (rats in diestrus I and II phases); b) High hormone levels (proestrus/estrus phases); c) No hormones (ovariectomized rats); and d) Rats under progesterone withdrawal (PW). To evaluate the participation of the GABAA receptor in the anxiolytic-like action of MT the antagonist picrotoxin was used. Results: Results showed that MT induced dose-dependent anxiolytic-like actions in rats with low hormone level conditions. Also, MT reduced anxiety-like behavior in female rats under PW, in contrast to diazepam which was ineffective. MT's anxiolytic-like effect was blocked by picrotoxin, suggesting the participation of the GABAA receptor complex. However, increased anxiety-like behavior was observed in rats with a high hormone level condition and low doses of MT. Conclusions: Beneficial anxiolytic-like actions of MT are observed under low hormone conditions, particularly in the PW challenge (a condition that can be related to a premenstrual period). Furthermore, the participation of the GABAA receptor is evidenced. However, hormonal variations could induce the opposite effects, hence women should be cautious.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevier Sequoiaes_ES
dc.relation241:112006
dc.rightsAcceso Cerradoes_ES
dc.titleAnxiolytic- and anxiogenic-like effects of Montanoa tomentosa (Asteraceae): Dependence on the endocrine conditiones_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñíz”, Calzada México Xochimilco 101, Col San Lorenzo Huipulco, Delegación Tlalpan, Ciudad de México, Mexico
dc.contributor.emailestrada@imp.edu.mx (E. Estrada-Camarena), sodi8507@gmail.com (I. Sollozo-Dupont), dannia.islas@hotmail.com (D. Islas-Preciado), evag@imp.edu.mx (M.E. González-Trujano), clopezr@cinvestav.mx (C. López-Rubalcava)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.identifier.placeIrlanda
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2019.112006
dc.subject.kwAnxiolytic-like effect
dc.subject.kwEstrous cycle
dc.subject.kwProgesterone withdrawal
dc.subject.kwElevated plus-maze
dc.subject.kwMontanoa tomentosa
dc.subject.kwGABAA receptor


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